Immune Signaling in Neurodegeneration

Neurodegenerative diseases of the central nervous system progressively rob patients of their memory, motor function, and ability to perform daily tasks. Advances in genetics and animal models are beginning to unearth an unexpected role of the immune system in disease onset and pathogenesis; however,...

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Bibliographic Details
Published in:	Immunity (Cambridge, Mass.) Mass.), 2019-04, Vol.50 (4), p.955-974
Main Authors:	Hammond, Timothy R., Marsh, Samuel E., Stevens, Beth
Format:	Article
Language:	English
Subjects:	Aging - immunology Alzheimer's disease Animal models Animals Central nervous system Complement Complement Activation Cytokine Cytokines Disease Progression Genetic Predisposition to Disease Genetics Genome-wide association studies Genome-Wide Association Study Genomes Gliosis - immunology Gliosis - pathology Growth factors GWAS Human motion Humans Immune system Immunity, Innate Immunotherapy Inflammation Inflammation - immunology Innate Immunity Inventors Membrane Glycoproteins - immunology Mice Mice, Knockout Mice, Transgenic Microglia Microglia - immunology Models, Immunological Neuro-immune Neurodegeneration Neurodegenerative diseases Neurodegenerative Diseases - genetics Neurodegenerative Diseases - immunology Neurodegenerative Diseases - pathology Neurodegenerative Diseases - therapy Neuroinflammation Neurological diseases Pathogenesis Pathology Protein Aggregation, Pathological - immunology Receptors, Immunologic - immunology Signal transduction Signal Transduction - immunology Signaling TGF-β Transforming Growth Factor beta - immunology TREM2
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