The importance of evaluating the chemical structures and strategies to avoid pitfalls in quantitative bioanalysis

Quantitative bioanalytical data are crucial in pharmaceutical research and development, allowing project teams to make informed scientific decisions on the progression of candidate molecules to medicines. Many challenges are often encountered during the bioanalysis of drugs in biological matrices wh...

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Bibliographic Details
Published in:Bioanalysis 2019-01, Vol.11 (2), p.85-101
Main Authors: Licea-Perez, Hermes, Evans, Christopher A, Summerfield, Scott G
Format: Article
Language:English
Subjects:
Acids
Amides
Amines
bioanalysis
chemical derivatization
chemical structure
Chemistry
Chromatography
Cytochrome
Drug development
Enzyme kinetics
Esters
glucuronide metabolites
Lactones
mass spectrometry
Metabolites
Methods
N-oxide metabolites
Oxides
Phosphates
Physiology
Prodrugs
stabilization of drugs
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Summary:Quantitative bioanalytical data are crucial in pharmaceutical research and development, allowing project teams to make informed scientific decisions on the progression of candidate molecules to medicines. Many challenges are often encountered during the bioanalysis of drugs in biological matrices which require resolution in a timely manner. In this publication, guidance is provided to bioanalytical scientists on how to identify potential problems before they become an obstacle for the drug development and to share our experiences dealing some of most common problems encountered in the bioanalytical laboratory. Relevant topics in bioanalysis such as stabilization approaches for glucuronides (Acyl and N-); prodrugs (phosphate and esters), amides, amines, N-oxides; bioanalysis of light sensitive molecules, halogenated drugs and lactones are discussed in this publication.
ISSN:1757-6180
1757-6199
DOI:10.4155/bio-2018-0211