Nonlamellar liquid crystals: a new paradigm for the delivery of small molecules and bio-macromolecules

The aim of this article is to collate the recent developments in the field of drug delivery, medical therapeutics and diagnostics specifically involving the nonlamellar liquid crystalline (NLC) systems. This review highlights different NLC phases having cubic, hexagonal and sponge internal structure...

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Bibliographic Details
Published in:Therapeutic delivery 2018-09, Vol.9 (9), p.667-689
Main Authors: Urandur, Sandeep, Marwaha, Disha, Gautam, Shalini, Banala, Venkatesh T, Sharma, Madhu, Mishra, Prabhat R
Format: Article
Language:English
Subjects:
active targeting
Biomedical materials
Cancer
Cancer therapies
Crystals
cubosomes
Drug delivery
Drugs
Fourier transforms
Gels
hexosomes
Hydration
Lipids
Macromolecules
Nanoparticles
passive targeting
peptide and protein delivery
Peptides
Pharmaceuticals
Phase transitions
Skin cancer
Surfactants
theranostic
Toxicity
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Summary:The aim of this article is to collate the recent developments in the field of drug delivery, medical therapeutics and diagnostics specifically involving the nonlamellar liquid crystalline (NLC) systems. This review highlights different NLC phases having cubic, hexagonal and sponge internal structures, and their application in the field of drug delivery, such as dose reduction, toxicity reduction and therapeutic efficacy enhancement either in the form of nanoparticles, colloidal dispersion or gels. In addition, application of NLC systems as vehicles for peptides, proteins and as a theranostic system in cancer and other disease conditions is also elaborated, which is a growing platform of interest. Overall, the present review gives us a complete outlook on applications of NLC systems in the field of medicine.
ISSN:2041-5990
2041-6008
DOI:10.4155/tde-2018-0038