Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1{alpha} in human skeletal muscle

1 Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada; 2 Department of Physiology, The University of Melbourne, Melbourne, Victoria; and 3 School of Exercise and Nutrition Sciences, Deakin University, Burwood, Victoria, Australia Submitted 8 July 2008 ; accepted in final form 2...

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Bibliographic Details
Published in:Journal of applied physiology (1985) 2009-03, Vol.106 (3), p.929
Main Authors: Gibala, Martin J, McGee, Sean L, Garnham, Andrew P, Howlett, Kirsten F, Snow, Rodney J, Hargreaves, Mark
Format: Article
Language:English
Subjects:
Cells
Exercise
Gene expression
Kinases
Musculoskeletal system
Physiology
Proteins
Signal transduction
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Summary:1 Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada; 2 Department of Physiology, The University of Melbourne, Melbourne, Victoria; and 3 School of Exercise and Nutrition Sciences, Deakin University, Burwood, Victoria, Australia Submitted 8 July 2008 ; accepted in final form 20 December 2008 From a cell signaling perspective, short-duration intense muscular work is typically associated with resistance training and linked to pathways that stimulate growth. However, brief repeated sessions of sprint or high-intensity interval exercise induce rapid phenotypic changes that resemble traditional endurance training. We tested the hypothesis that an acute session of intense intermittent cycle exercise would activate signaling cascades linked to mitochondrial biogenesis in human skeletal muscle. Biopsies (vastus lateralis) were obtained from six young men who performed four 30-s "all out" exercise bouts interspersed with 4 min of rest (
ISSN:8750-7587
1522-1601
DOI:10.1152/japplphysiol.90880.2008