Dose-dependent relationship between severity of pediatric obesity and blunting of the growth hormone response to exercise

1 Department of Pharmacology, School of Medicine, University of California, Irvine; and ; 2 Institute for Clinical and Translational Science, Department of Pediatrics, University of California, Irvine, Orange, California Submitted 2 June 2009 ; accepted in final form 28 October 2009 In children, exe...

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Published in:Journal of applied physiology (1985) 2010-01, Vol.108 (1), p.21-27
Main Authors: Oliver, Stacy R, Rosa, Jaime S, Minh, Timothy D. C, Pontello, Andria M, Flores, Rebecca L, Barnett, Marcia, Galassetti, Pietro R
Format: Article
Language:English
Subjects:
Adaptation, Physiological
Adolescent
Biological and medical sciences
Body Size
Exercise
Female
Fundamental and applied biological sciences. Psychology
Growth hormones
Humans
Insulin-Like Growth Factor I - metabolism
Male
Obesity
Obesity - physiopathology
Pediatrics
Physical Exertion
Plasma
Puberty
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Summary:1 Department of Pharmacology, School of Medicine, University of California, Irvine; and ; 2 Institute for Clinical and Translational Science, Department of Pediatrics, University of California, Irvine, Orange, California Submitted 2 June 2009 ; accepted in final form 28 October 2009 In children, exercise modulates systemic anabolism, muscle growth, and overall physiological development through the growth hormone (GH)-insulin-like growth factor I (IGF-I) axis. GH secretion, at rest and during exercise, changes with age and maturational status and can be blunted by hyperlipidemia and obesity, with possible negative effects on physiological growth. However, little is known about the effect of progressively more severe pediatric obesity on the GH response to exercise and its relationship to pubertal status. We therefore studied 48 early- or late-pubertal obese children [body mass index (BMI) >95th percentile, separated in tertiles with progressively greater BMI] and 42 matched controls (BMI
ISSN:8750-7587
1522-1601
DOI:10.1152/japplphysiol.00589.2009