Cardiovascular responses to exercise and muscle metaboreflex activation during the recovery from pacing-induced heart failure

• Published in: Journal of applied physiology (1985) 2006-07, Vol.101 (1), p.14-22
• Main Authors: Augustyniak, Robert A, Ansorge, Eric J, Kim, Jong-Kyung, Sala-Mercado, Javier A, Hammond, Robert L, Rossi, Noreen F, O'Leary, Donal S
• Format: Article
• Language: English
• Subjects: Animals; Biological and medical sciences; Cardiac Output - physiology; Cardiac Output, Low - physiopathology; Cardiac Pacing, Artificial; Cardiology; Cardiovascular Physiological Phenomena; Cardiovascular system; Dogs; Exercise; Female; Fundamental and applied biological sciences. Psychology; Heart failure; Hemodynamics - physiology; Hindlimb - blood supply; Male; Muscle, Skeletal - blood supply; Muscle, Skeletal - innervation; Muscle, Skeletal - physiopathology; Physical Conditioning, Animal - physiology; Recovery of Function - physiology; Reflex - physiology; Regional Blood Flow - physiology; Rest - physiology; Stroke Volume - physiology; Studies; Sympathetic Nervous System - physiology; Time Factors
• ISSN: 8750-7587; 1522-1601
• DOI: 10.1152/japplphysiol.00072.2006

Departments of 1 Physiology, 2 Internal Medicine, and 3 Surgery, Wayne State University School of Medicine, and 4 Department of Medicine, John D. Dingell Veterans Affairs Medical Center, Detroit, Michigan Submitted 20 January 2006 ; accepted in final form 30 March 2006 Rapid recovery of resting hemodynamics from tachycardia- or arrhythmia-induced heart failure (HF) has been demonstrated in both humans and animals. However, little is known about cardiovascular responses to exercise in animals or about reflex control of the cardiovascular system during exercise while recovering from HF. Inasmuch as the reduced cardiac output (CO) during exercise in HF has been shown to lead to underperfusion of active skeletal muscle and tonic activation of the muscle metaboreflex, an improved CO during exercise in subjects recovering from HF may lead to higher skeletal muscle blood flows and to relief of this metabolic stimulus. We investigated cardiovascular responses to graded treadmill exercise and metaboreflex activation [evoked by imposed graded reductions in hindlimb blood flow (HLBF) during mild and moderate exercise] in chronically instrumented dogs during control, mild to moderate HF (induced by rapid ventricular pacing), and recovery from HF. Most hemodynamic responses to graded exercise returned to control within 24 h of disconnecting the pacemaker. After 2 wk of recovery, CO and HLBF at each workload were significantly higher than control. In addition, whereas the increase in CO that normally occurs with metaboreflex activation was markedly attenuated in HF, it completely returned in the recovery experiments. We conclude that cardiovascular responses to graded exercise during the recovery from pacing-induced HF return rapidly to near or above control and that the increased CO and HLBF in recovery likely relieved the metabolic stimulus and tonic metaboreflex activation that may have occurred during moderate exercise in HF. skeletal muscle ischemia; muscle chemoreflex; muscle afferents; central venous pressure; heart rate; vascular conductance; sympathetic nerve activity; graded exercise Address for reprint requests and other correspondence: D. S. O'Leary, Dept. of Physiology, Wayne State Univ. School of Medicine, 540 East Canfield Ave., Detroit, MI 48201 (e-mail: doleary{at}med.wayne.edu )