Surface stabilization treatment enhances initial cell viability and adhesion for biodegradable zinc alloys

•Surface stabilization treatment created a stable surface oxide film of ∼300 nm.•The surface layer was enriched with Zn(OH)2 and ZnO.•This layer substantially increased cell viability in both direct & indirect assays. Zinc-based alloys hold promise as next generation biodegradable implants. Alth...

Full description

Saved in:
Bibliographic Details
Published in:Materials letters 2019-08, Vol.248, p.130-133
Main Authors: Katarivas Levy, Galit, Kafri, Alon, Ventura, Yvonne, Leon, Avi, Vago, Razi, Goldman, Jeremy, Aghion, Eli
Format: Article
Language:English
Subjects:
Biocompatibility
Biodegradability
Biodegradable zinc-based alloy
Biomedical materials
Cytotoxicity
In-vitro testing
Materials science
Oxide coatings
Stabilization
Surface treatment
Surgical implants
Thickness
Transplants & implants
Zinc base alloys
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•Surface stabilization treatment created a stable surface oxide film of ∼300 nm.•The surface layer was enriched with Zn(OH)2 and ZnO.•This layer substantially increased cell viability in both direct & indirect assays. Zinc-based alloys hold promise as next generation biodegradable implants. Although zinc implants exhibit excellent biocompatibility in vivo, they have been found to inhibit cell attachment and viability under in vitro conditions. In order to clarify the cell response disparity and improve the biocompatibility of zinc implant materials, Zn-1Mg and Zn-1Mg-0.5Ca alloys underwent surface stabilization treatment in cell culture medium. Surface processing resulted in a stable surface oxide film of ∼300 nm thickness. The stability of the oxide layer substantially increased the viability of cells in both direct and indirect contact assays. It is consequently believed that the surface film characteristics of zinc implants may be an important determinant of biocompatibility.
ISSN:0167-577X
1873-4979
DOI:10.1016/j.matlet.2019.04.006