The role of pH, metal ions and their hydroxides in charge reversal of protein-coated nanoparticles

In this study, we investigated charge inversion of protein-coated Au nanoparticles caused by the addition of metal ions. The addition of hydrolyzable metal ions (Lewis acids) can induce drastic pH changes and depending on this pH, the metal ions ( e.g. M 3+ ) are readily converted into the hydrolyze...

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Bibliographic Details
Published in:Physical chemistry chemical physics : PCCP 2019-05, Vol.21 (21), p.1111-1118
Main Authors: Schubert, Jonas, Radeke, Carmen, Fery, Andreas, Chanana, Munish
Format: Article
Language:English
Subjects:
Charge reversal
Gold
Hydroxides
Ions
Metal ions
Nanoparticles
Proteins
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Summary:In this study, we investigated charge inversion of protein-coated Au nanoparticles caused by the addition of metal ions. The addition of hydrolyzable metal ions (Lewis acids) can induce drastic pH changes and depending on this pH, the metal ions ( e.g. M 3+ ) are readily converted into the hydrolyzed species (MOH 2+ , M(OH) 2 + ) or even into hydroxides (M(OH) 3 ). Adsorbed metal hydroxides were identified to cause the charge inversion of the NPs by using a combination of cryo-TEM, EFTEM and ζ -potential measurements. In this study, we investigated charge inversion of protein-coated Au nanoparticles caused by the addition of metal ions. Adsorbed metal hydroxides were identified to cause the charge inversion of the NPs by using a combination of cryo-TEM, EFTEM and ζ -potential measurements.
ISSN:1463-9076
1463-9084
DOI:10.1039/c8cp05946b