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Nucleoside alkaloids with anti-platelet aggregation activity from the rhizomes of Ligusticum striatum
Two new (1-2) and six known (3-8) nucleoside alkaloids were isolated from the rhizomes of Ligusticum striatum DC. Compounds 1 and 2 (liguadenosines A and B) were unusual N-10 substituted adenosine derivatives. Their structures were elucidated by extensive spectroscopic analyses and ECD calculation....
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| Published in: | Natural product research 2019-05, Vol.33 (10), p.1399-1405 |
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| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c441t-e582f323f9392305b8ed314edd055be506bc4ba92d5cca75ea67309b5468808b3 |
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| cites | cdi_FETCH-LOGICAL-c441t-e582f323f9392305b8ed314edd055be506bc4ba92d5cca75ea67309b5468808b3 |
| container_end_page | 1405 |
| container_issue | 10 |
| container_start_page | 1399 |
| container_title | Natural product research |
| container_volume | 33 |
| creator | Pu, Zhong-Hui Liu, Juan Peng, Cheng Luo, Min Zhou, Qin-Mei Xie, Xiao-Fang Chen, Ming-Hua Xiong, Liang |
| description | Two new (1-2) and six known (3-8) nucleoside alkaloids were isolated from the rhizomes of Ligusticum striatum DC. Compounds 1 and 2 (liguadenosines A and B) were unusual N-10 substituted adenosine derivatives. Their structures were elucidated by extensive spectroscopic analyses and ECD calculation. Most of them significantly inhibited the abnormal increase in platelet aggregation induced by ADP at concentrations of 50 and 100 μM. Particularly, the inhibitory effect of 3 was equivalent to aspirin. |
| doi_str_mv | 10.1080/14786419.2017.1416382 |
| format | article |
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Compounds 1 and 2 (liguadenosines A and B) were unusual N-10 substituted adenosine derivatives. Their structures were elucidated by extensive spectroscopic analyses and ECD calculation. Most of them significantly inhibited the abnormal increase in platelet aggregation induced by ADP at concentrations of 50 and 100 μM. Particularly, the inhibitory effect of 3 was equivalent to aspirin.</description><identifier>ISSN: 1478-6419</identifier><identifier>EISSN: 1478-6427</identifier><identifier>DOI: 10.1080/14786419.2017.1416382</identifier><identifier>PMID: 29262724</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Adenosine ; adenosine derivatives ; Adenosine diphosphate ; Agglomeration ; Alkaloids ; Alkaloids - isolation & purification ; Alkaloids - pharmacology ; anti-platelet aggregation activity ; Aquatic plants ; Aspirin ; Aspirin - pharmacology ; Humans ; Ligusticum ; Ligusticum - chemistry ; Ligusticum striatum ; Molecular Structure ; Neostriatum ; nucleoside ; Nucleosides ; Nucleosides - pharmacology ; Platelet Activating Factor ; Platelet aggregation ; Platelet Aggregation - drug effects ; Platelet Aggregation Inhibitors - chemistry ; Platelet Aggregation Inhibitors - isolation & purification ; Platelet Aggregation Inhibitors - pharmacology ; Rhizome - chemistry ; Rhizomes</subject><ispartof>Natural product research, 2019-05, Vol.33 (10), p.1399-1405</ispartof><rights>2017 Informa UK Limited, trading as Taylor & Francis Group 2017</rights><rights>2017 Informa UK Limited, trading as Taylor & Francis Group</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-e582f323f9392305b8ed314edd055be506bc4ba92d5cca75ea67309b5468808b3</citedby><cites>FETCH-LOGICAL-c441t-e582f323f9392305b8ed314edd055be506bc4ba92d5cca75ea67309b5468808b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29262724$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pu, Zhong-Hui</creatorcontrib><creatorcontrib>Liu, Juan</creatorcontrib><creatorcontrib>Peng, Cheng</creatorcontrib><creatorcontrib>Luo, Min</creatorcontrib><creatorcontrib>Zhou, Qin-Mei</creatorcontrib><creatorcontrib>Xie, Xiao-Fang</creatorcontrib><creatorcontrib>Chen, Ming-Hua</creatorcontrib><creatorcontrib>Xiong, Liang</creatorcontrib><title>Nucleoside alkaloids with anti-platelet aggregation activity from the rhizomes of Ligusticum striatum</title><title>Natural product research</title><addtitle>Nat Prod Res</addtitle><description>Two new (1-2) and six known (3-8) nucleoside alkaloids were isolated from the rhizomes of Ligusticum striatum DC. Compounds 1 and 2 (liguadenosines A and B) were unusual N-10 substituted adenosine derivatives. Their structures were elucidated by extensive spectroscopic analyses and ECD calculation. Most of them significantly inhibited the abnormal increase in platelet aggregation induced by ADP at concentrations of 50 and 100 μM. Particularly, the inhibitory effect of 3 was equivalent to aspirin.</description><subject>Adenosine</subject><subject>adenosine derivatives</subject><subject>Adenosine diphosphate</subject><subject>Agglomeration</subject><subject>Alkaloids</subject><subject>Alkaloids - isolation & purification</subject><subject>Alkaloids - pharmacology</subject><subject>anti-platelet aggregation activity</subject><subject>Aquatic plants</subject><subject>Aspirin</subject><subject>Aspirin - pharmacology</subject><subject>Humans</subject><subject>Ligusticum</subject><subject>Ligusticum - chemistry</subject><subject>Ligusticum striatum</subject><subject>Molecular Structure</subject><subject>Neostriatum</subject><subject>nucleoside</subject><subject>Nucleosides</subject><subject>Nucleosides - pharmacology</subject><subject>Platelet Activating Factor</subject><subject>Platelet aggregation</subject><subject>Platelet Aggregation - drug effects</subject><subject>Platelet Aggregation Inhibitors - chemistry</subject><subject>Platelet Aggregation Inhibitors - isolation & purification</subject><subject>Platelet Aggregation Inhibitors - pharmacology</subject><subject>Rhizome - chemistry</subject><subject>Rhizomes</subject><issn>1478-6419</issn><issn>1478-6427</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kctu2zAQRYmiRfPqJ7Qg0E02cvmUyF2KoHkARrJJ1gRFjWymlOiQVAP36yvDThZdZDWDwbl3BnMR-krJghJFflDRqFpQvWCENgsqaM0V-4COd_OqFqz5-NZTfYROcn4ihFEp5Wd0xDSrWcPEMYK7yQWI2XeAbfhtQ_Rdxi--rLEdi682wRYIULBdrRKsbPFxxNYV_8eXLe5THHBZA05r_zcOkHHs8dKvply8mwacS_K2TMMZ-tTbkOHLoZ6ix6tfD5c31fL--vby57JyQtBSgVSs54z3mmvGiWwVdJwK6DoiZQuS1K0TrdWsk87ZRoKtG050K0WtFFEtP0Xne99Nis8T5GIGnx2EYEeIUzZUN1poNXvP6Pf_0Kc4pXG-zjDGmeCCqGam5J5yKeacoDeb5AebtoYSs8vBvOZgdjmYQw6z7tvBfWoH6N5Ur4-fgYs94Mc-psG-xBQ6U-w2xNQnOzqfDX9_xz-mRpfy</recordid><startdate>20190519</startdate><enddate>20190519</enddate><creator>Pu, Zhong-Hui</creator><creator>Liu, Juan</creator><creator>Peng, Cheng</creator><creator>Luo, Min</creator><creator>Zhou, Qin-Mei</creator><creator>Xie, Xiao-Fang</creator><creator>Chen, Ming-Hua</creator><creator>Xiong, Liang</creator><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7T7</scope><scope>7TK</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20190519</creationdate><title>Nucleoside alkaloids with anti-platelet aggregation activity from the rhizomes of Ligusticum striatum</title><author>Pu, Zhong-Hui ; Liu, Juan ; Peng, Cheng ; Luo, Min ; Zhou, Qin-Mei ; Xie, Xiao-Fang ; Chen, Ming-Hua ; Xiong, Liang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-e582f323f9392305b8ed314edd055be506bc4ba92d5cca75ea67309b5468808b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adenosine</topic><topic>adenosine derivatives</topic><topic>Adenosine diphosphate</topic><topic>Agglomeration</topic><topic>Alkaloids</topic><topic>Alkaloids - isolation & purification</topic><topic>Alkaloids - pharmacology</topic><topic>anti-platelet aggregation activity</topic><topic>Aquatic plants</topic><topic>Aspirin</topic><topic>Aspirin - pharmacology</topic><topic>Humans</topic><topic>Ligusticum</topic><topic>Ligusticum - chemistry</topic><topic>Ligusticum striatum</topic><topic>Molecular Structure</topic><topic>Neostriatum</topic><topic>nucleoside</topic><topic>Nucleosides</topic><topic>Nucleosides - pharmacology</topic><topic>Platelet Activating Factor</topic><topic>Platelet aggregation</topic><topic>Platelet Aggregation - drug effects</topic><topic>Platelet Aggregation Inhibitors - chemistry</topic><topic>Platelet Aggregation Inhibitors - isolation & purification</topic><topic>Platelet Aggregation Inhibitors - pharmacology</topic><topic>Rhizome - chemistry</topic><topic>Rhizomes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pu, Zhong-Hui</creatorcontrib><creatorcontrib>Liu, Juan</creatorcontrib><creatorcontrib>Peng, Cheng</creatorcontrib><creatorcontrib>Luo, Min</creatorcontrib><creatorcontrib>Zhou, Qin-Mei</creatorcontrib><creatorcontrib>Xie, Xiao-Fang</creatorcontrib><creatorcontrib>Chen, Ming-Hua</creatorcontrib><creatorcontrib>Xiong, Liang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Natural product research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pu, Zhong-Hui</au><au>Liu, Juan</au><au>Peng, Cheng</au><au>Luo, Min</au><au>Zhou, Qin-Mei</au><au>Xie, Xiao-Fang</au><au>Chen, Ming-Hua</au><au>Xiong, Liang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nucleoside alkaloids with anti-platelet aggregation activity from the rhizomes of Ligusticum striatum</atitle><jtitle>Natural product research</jtitle><addtitle>Nat Prod Res</addtitle><date>2019-05-19</date><risdate>2019</risdate><volume>33</volume><issue>10</issue><spage>1399</spage><epage>1405</epage><pages>1399-1405</pages><issn>1478-6419</issn><eissn>1478-6427</eissn><abstract>Two new (1-2) and six known (3-8) nucleoside alkaloids were isolated from the rhizomes of Ligusticum striatum DC. 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| ispartof | Natural product research, 2019-05, Vol.33 (10), p.1399-1405 |
| issn | 1478-6419 1478-6427 |
| language | eng |
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| source | Taylor and Francis Science and Technology Collection |
| subjects | Adenosine adenosine derivatives Adenosine diphosphate Agglomeration Alkaloids Alkaloids - isolation & purification Alkaloids - pharmacology anti-platelet aggregation activity Aquatic plants Aspirin Aspirin - pharmacology Humans Ligusticum Ligusticum - chemistry Ligusticum striatum Molecular Structure Neostriatum nucleoside Nucleosides Nucleosides - pharmacology Platelet Activating Factor Platelet aggregation Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - chemistry Platelet Aggregation Inhibitors - isolation & purification Platelet Aggregation Inhibitors - pharmacology Rhizome - chemistry Rhizomes |
| title | Nucleoside alkaloids with anti-platelet aggregation activity from the rhizomes of Ligusticum striatum |
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