Incidence and clinical impact of perianal disease in patients with ulcerative colitis: A nationwide population‐based study

• Published in: Journal of gastroenterology and hepatology 2019-06, Vol.34 (6), p.1011-1017
• Main Authors: Song, Eun Mi, Lee, Ho‐Su, Kim, Ye‐Jee, Oh, Eun Hye, Ham, Nam Seok, Kim, Jeongseok, Hwang, Sung Wook, Park, Sang Hyoung, Yang, Dong‐Hoon, Ye, Byong Duk, Byeon, Jeong‐Sik, Myung, Seung‐Jae, Yang, Suk‐Kyun
• Format: Article
• Language: English
• Subjects: Adolescent; Adrenal Cortex Hormones - adverse effects; Adult; Aged; anus diseases; Anus Diseases - epidemiology; Anus Diseases - etiology; Child; Child, Preschool; Cohort Studies; Colectomy - statistics & numerical data; Colitis, Ulcerative - complications; Colitis, Ulcerative - epidemiology; Confidence intervals; Corticosteroids; Diagnosis; Drug Utilization - statistics & numerical data; Female; fistula; Health risk assessment; Hospitals - statistics & numerical data; Humans; Incidence; Infant; Inflammatory bowel disease; Male; Middle Aged; Patients; Population; Population studies; Population-based studies; Prognosis; Republic of Korea - epidemiology; Risk; Time Factors; Tumor Necrosis Factor-alpha - antagonists & inhibitors; Ulcerative colitis; Young Adult
• ISSN: 0815-9319; 1440-1746
• DOI: 10.1111/jgh.14555

Background and Aim The risk and clinical impact of perianal disease (PAD) in ulcerative colitis (UC) patients have not been fully evaluated. We investigated the incidence of PAD in UC patients and compared clinical characteristics and outcomes of UC according to the presence of PAD. Methods We performed a nationwide population‐based cohort study and a hospital‐based cohort study. Using the 2010–2014 data from the Korean National Health Insurance claims database, we calculated incidence rates and standardized incidence ratios of PAD in UC patients compared with the general population. We evaluated the clinical characteristics and outcomes of UC patients with PAD in both population‐based and hospital‐based cohorts. To reduce clinically meaningful confounding factors, we also conducted matched analyses. Results In the population‐based cohort, the incidence rate and standardized incidence ratio of PAD in UC patients were 3.74/1000 person‐years (95% confidence interval, 3.25–4.31) and 2.88 (95% confidence interval, 2.50–3.32), respectively. In the hospital‐based cohort, the cumulative probabilities of PAD at 1, 5, 10, and 20 years after diagnosis were 1.0%, 2.3%, 4.0%, and 6.3%, respectively. In both population‐based and hospital‐based cohorts, UC patients with PAD showed higher proportions of corticosteroid use and extensive colitis at diagnosis. The requirements for anti‐tumor necrosis factor agents and colectomy were significantly higher in UC patients with PAD before and after matched analysis. Conclusions The risk of PAD is higher in UC patients than in the general population. UC patients with PAD have distinct clinical features and poor outcomes, as indicated by the greater need for UC‐related medications and colectomy.