Modular 3D Printed Compressed Air Driven Continuous‐Flow Systems for Chemical Synthesis

In this present study, we describe the development of a low‐cost, small‐footprint and modular 3D printed continuous‐flow system that readily attaches to existing stirrer hotplates. Flow‐rates are controlled by compressed air that is typically present in all fume hoods, making it suitable for use by...

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Bibliographic Details
Published in:European journal of organic chemistry 2019-06, Vol.2019 (23), p.3783-3787
Main Authors: Penny, Matthew R., Rao, Zenobia X., Peniche, Bruno Felício, Hilton, Stephen T.
Format: Article
Language:English
Subjects:
3D‐Printing
Chemical synthesis
Chemists
Compressed air
Continuous flow
Corrosion resistance
Fume cupboards
Heterocycles
Modularity
Organic chemistry
Polypropylene
Reactionware
Reactors
Retirement
Synthetic methods
Three dimensional flow
Three dimensional printing
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Summary:In this present study, we describe the development of a low‐cost, small‐footprint and modular 3D printed continuous‐flow system that readily attaches to existing stirrer hotplates. Flow‐rates are controlled by compressed air that is typically present in all fume hoods, making it suitable for use by synthetic chemists. The length of the flow‐path and reaction residence time is regulated by control of the air‐flow and pressure and by addition of one or more 3D printed polypropylene (PP) circular disk reactors that were designed to fit a DrySyn Multi‐E base, which is found in most synthetic laboratories. The ease of use of the system, the facile control of flow‐rates and the solvent resistance of the PP reactors was demonstrated in a range of SNAr reactions to produce substituted ether derivatives highlighting the utility and modularity of the system. A low‐cost, small‐footprint, modular 3D printed continuous‐flow system that could be attached to existing stirrer hotplates was developed and tested in a range of SNAr reactions to produce substituted ether derivatives. Flow‐rates are controlled by compressed air typically present in all fume hoods, and the length of the flow‐path and reaction residence time is regulated by 3D printed polypropylene (PP) circular disk reactors.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.201900423