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Catalytic Asymmetric Transfer Hydrogenation of Ketones Using [Ru(p-cymene)Cl₂]₂ with Chiral Amino Alcohol Ligands
Catalytic asymmetric transfer hydrogenation of aromatic alkyl ketones has been investigated using [Ru(p-cymene)Cl₂]₂ and new derivatives of β-amino alcohols synthesized from (S)-(−)-lactic acid and mandelic acid as ligands. Chiral secondary alcohols were obtained with good to excellent conversion (6...
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Published in: | Catalysis letters 2010-09, Vol.138 (3-4), p.231-238 |
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Main Authors: | , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Catalytic asymmetric transfer hydrogenation of aromatic alkyl ketones has been investigated using [Ru(p-cymene)Cl₂]₂ and new derivatives of β-amino alcohols synthesized from (S)-(−)-lactic acid and mandelic acid as ligands. Chiral secondary alcohols were obtained with good to excellent conversion (60-90%) and moderate to good enantioselectivities (40-86%). Graphical Abstract Asymmetric transfer hydrogenation of ketones has been investigated using [Ru(p-cymene)Cl₂]₂ and β-amino alcohols synthesized from (S)-(−)-lactic acid and Mandelic acid as ligands. Chiral secondary alcohols were obtained with good to excellent conversion (60-90%) and moderate to good enantioselectivities (40-86%). [graphic removed] |
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ISSN: | 1011-372X 1572-879X |
DOI: | 10.1007/s10562-010-0408-y |