Loading…

Catalytic Asymmetric Transfer Hydrogenation of Ketones Using [Ru(p-cymene)Cl₂]₂ with Chiral Amino Alcohol Ligands

Catalytic asymmetric transfer hydrogenation of aromatic alkyl ketones has been investigated using [Ru(p-cymene)Cl₂]₂ and new derivatives of β-amino alcohols synthesized from (S)-(−)-lactic acid and mandelic acid as ligands. Chiral secondary alcohols were obtained with good to excellent conversion (6...

Full description

Saved in:
Bibliographic Details
Published in:Catalysis letters 2010-09, Vol.138 (3-4), p.231-238
Main Authors: Deshpande, Sudhindra H, Kelkar, Ashutosh A, Gonnade, Rajesh G, Shingote, Savita K, Chaudhari, Raghunath V
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Catalytic asymmetric transfer hydrogenation of aromatic alkyl ketones has been investigated using [Ru(p-cymene)Cl₂]₂ and new derivatives of β-amino alcohols synthesized from (S)-(−)-lactic acid and mandelic acid as ligands. Chiral secondary alcohols were obtained with good to excellent conversion (60-90%) and moderate to good enantioselectivities (40-86%). Graphical Abstract Asymmetric transfer hydrogenation of ketones has been investigated using [Ru(p-cymene)Cl₂]₂ and β-amino alcohols synthesized from (S)-(−)-lactic acid and Mandelic acid as ligands. Chiral secondary alcohols were obtained with good to excellent conversion (60-90%) and moderate to good enantioselectivities (40-86%). [graphic removed]
ISSN:1011-372X
1572-879X
DOI:10.1007/s10562-010-0408-y