Loading…

Domain-specific patterns of physical activity and risk of breast cancer sub-types in the MCC-Spain study

Purpose Literature on the separate effects of physical activities (PA) on risk of breast cancer (BC) sub-types is heterogeneous. We investigated domain-specific associations between PA and BC risk by menopausal status and molecular subtype. Methods 1389 histologically confirmed invasive BC cases and...

Full description

Saved in:
Bibliographic Details
Published in:Breast cancer research and treatment 2019-10, Vol.177 (3), p.749-760
Main Authors: Huerta, José M., Molina, Antonio J., Chirlaque, María Dolores, Yepes, Pedro, Moratalla-Navarro, Ferrán, Moreno, Víctor, Amiano, Pilar, Guevara, Marcela, Moreno-Iribas, Conchi, Llorca, Javier, Fernández-Tardón, Guillermo, Molina-Barceló, Ana, Alguacil, Juan, Marcos-Gragera, Rafael, Castaño-Vinyals, Gemma, Pérez-Gómez, Beatriz, Kogevinas, Manolis, Pollán, Marina, Martín, Vicente
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose Literature on the separate effects of physical activities (PA) on risk of breast cancer (BC) sub-types is heterogeneous. We investigated domain-specific associations between PA and BC risk by menopausal status and molecular subtype. Methods 1389 histologically confirmed invasive BC cases and 1712 controls from the MCC-Spain study were included (age: 20–85 years). Questionnaire information on PA at work, at home, and during leisure time, including recreational PA and sedentary time, and data on reproductive history, anthropometry, family history of BC, diet, and lifestyles were obtained through face-to-face interviews. Information on the expression of oestrogen (ER), progesterone (PR), and HER2 receptors was available for > 95% of the cases. Mixed-effects multivariable logistic regression models were used to estimate odds ratios (OR) of BC sub-types. Results Occupational PA (OPA) intensity was associated with higher BC risk. Associations were stronger for pre-menopausal (OR active/very active vs. sedentary job 1.89; 95% confidence interval (CI) 1.22, 2.91) and ER+/PR+, HER2− tumours (OR 1.80; 95% CI 1.28, 2.53). Sedentary time was associated with higher risk of post-menopausal BC (OR 6−9 vs.
ISSN:0167-6806
1573-7217
DOI:10.1007/s10549-019-05358-x