Evaluation of poly(hydroxyethyl acrylate/itaconic acid) hydrogels for controlled delivery of transition metal complexes with Oxaprozin as potential antiproliferative agents

A series of dual-sensitive poly(2-hydroxyethyl acrylate/itaconic acid) (P(HEA/IA)) hydrogels were synthesized and evaluated as drug delivery systems for potential antiproliferative agents. Investigated hydrophobic compounds, Mn(II) and Zn(II) complexes with Oxaprozin, were efficiently loaded into th...

Full description

Saved in:
Bibliographic Details
Published in:Journal of materials science 2015-09, Vol.50 (18), p.6208-6219
Main Authors: Babic, Marija M, Bozic, Bojan D, Bozic, Biljana D, Filipovic, Jovanka M, Uscumlic, Gordana S, Tomic, Simonida Lj
Format: Article
Language:English
Subjects:
Analysis
Antiproliferatives
Characterization and Evaluation of Materials
Chemistry and Materials Science
Classical Mechanics
Colon
colorectal neoplasms
complexing
Coordination compounds
Crystallography and Scattering Methods
Drug delivery systems
Fourier transform infrared spectroscopy
humans
hydrocolloids
Hydrogels
Hydrophobicity
Hydroxyethyl acrylate
intestines
Itaconic acid
loading
manganese
Materials Science
melanoma
Nonsteroidal anti-inflammatory agents
Original Paper
Polymer Sciences
Solid Mechanics
temperature
Transition metal compounds
zinc
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A series of dual-sensitive poly(2-hydroxyethyl acrylate/itaconic acid) (P(HEA/IA)) hydrogels were synthesized and evaluated as drug delivery systems for potential antiproliferative agents. Investigated hydrophobic compounds, Mn(II) and Zn(II) complexes with Oxaprozin, were efficiently loaded into the P(HEA/IA) hydrogels, which was confirmed by FTIR and UV–Vis spectroscopy. Swelling studies, conducted in the physiological pH range of 2.20–8.00 and in temperature range of 30–50 °C, demonstrated that loaded transition metal complexes in P(HEA/IA) hydrogels did not annul pH and temperature sensitivity of the hydrogels. In vitro antiproliferative activity of Mn(II) and Zn(II) complexes with Oxaprozin against human cervical (HeLa) and melanoma cancer (Fem X) cell lines was tested. Results of in vitro release study investigated at different pH conditions confirmed P(HEA/IA) hydrogels as a highly effective pH-triggered drug delivery system for hydrophobic antiproliferative agents. These performances indicate that P(HEA/IA) hydrogels loaded with transition metal complexes can be further studied as a promising candidate for anticancer therapy, as well as for targeted treatment of intestine/colon cancers.
ISSN:0022-2461
1573-4803
DOI:10.1007/s10853-015-9179-6