Characterization of bilayer bacterial cellulose membranes with different fiber densities: a promising system for controlled release of the antibiotic ceftriaxone

This work describes the synthesis of bilayer bacterial cellulose membranes (BCs) produced by Gluconacetobacter hansenii ATCC 23769 in culture media with different carbon sources (sugarcane molasses, syrup and fructose) as well as their retention capacity and sustained release of the antibacterial ag...

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Bibliographic Details
Published in:Cellulose (London) 2016-02, Vol.23 (1), p.737-748
Main Authors: Lazarini, Silmara C, de Aquino, Renata, Amaral, André C, Corbi, Fabiana C. A, Corbi, Pedro P, Barud, Hernane S, Lustri, Wilton R
Format: Article
Language:English
Subjects:
Antibiotics
Bacteria
Bioorganic Chemistry
carbon
ceftriaxone
Cellulose
Cellulose fibers
Ceramics
Chemistry
Chemistry and Materials Science
Composites
Controlled release
culture media
Fourier transform infrared spectroscopy
Fourier transforms
Fructose
Glass
Gluconacetobacter hansenii
Infrared analysis
Membranes
Molasses
Natural Materials
Organic Chemistry
Original Paper
Physical Chemistry
Polymer Sciences
scanning electron microscopy
Staphylococcus aureus
Sugarcane
Sustainable Development
Sustained release
Syrup
Syrups & sweeteners
thermogravimetry
X-ray diffraction
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Summary:This work describes the synthesis of bilayer bacterial cellulose membranes (BCs) produced by Gluconacetobacter hansenii ATCC 23769 in culture media with different carbon sources (sugarcane molasses, syrup and fructose) as well as their retention capacity and sustained release of the antibacterial agent ceftriaxone. Scanning electronic microscopy analysis showed that BCs produced in all culture media exhibit a double layer and three-dimensional fiber network obtained in only one step. Elemental and thermogravimetric analyses, Fourier transform infrared spectroscopy and X-ray diffraction show that the BC membranes are composed of pure cellulose. In particular, the BC produced in sugarcane molasses medium presented a three-dimensional network structure of the bilayer with high-density fiber entangling, which was responsible for the largest holding capacity and sustained release of the antibiotic ceftriaxone in relation to Staphylococcus aureus bacterial strains. This behavior shows the potential of applying such BC membranes in wound dressings as a sustained support to release different antibiotics to treat skin infections.
ISSN:0969-0239
1572-882X
DOI:10.1007/s10570-015-0843-4