Chemometric-Assisted UV Spectrophotometric Method for Determination of Cefixime Trihydrate and Cloxacillin Sodium in Pharmaceutical Dosage Form

Multivariate calibration methods (e.g., multiple linear regression(MLR), principle component regression (PCR) and partial least squares (PLS) utilizing spectrophotometric data are the important Chemometrics approach for determination of mixtures including drugs combination [19]. Unscrambler X (10.5)...

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Bibliographic Details
Published in:Asian Journal of Research in Chemistry 2018-07, Vol.11 (4), p.705-709
Main Authors: Gandhi, Santosh V., Sonawane, Pratidnya S.
Format: Article
Language:English
Subjects:
Antibiotics
Calibration
Chemistry
Chemometrics
Drug dosages
International conferences
Methods
Pharmaceuticals
Pharmacy
Reagents
Simultaneous equations
Sodium
Software
Spectrophotometry
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Summary:Multivariate calibration methods (e.g., multiple linear regression(MLR), principle component regression (PCR) and partial least squares (PLS) utilizing spectrophotometric data are the important Chemometrics approach for determination of mixtures including drugs combination [19]. Unscrambler X (10.5) (64-bit) trial version and Microsoft Excel 2007 were used for model generation and application of Chemometric method. 2.2)Material and Reagents: Reference standard of CFX and CLOXA were obtained from Cadila Pharmaceuticals Ltd, Gujarat and KDLBiotech Pharmaceutical Industries Ltd, Mumbai, respectively as gift sample. (ProQuest: ... denotes formula omitted.) Where, RMSECV= Root mean square error of cross validation Cact= actual concentration of calibration set Cpre= predicted concentration of validation set Ic= Total number of samples in calibration set After the PCR and PLS models have been constructed, it was found that the optimum number of LVs were two factors for both PCR and PLS. Manwar VJ,Nagargoje BU, Gurumukhi VC, Ratnaparkhi DG.Warade PP, Kumbhar DD, Bakal RL, ManmodeRS.Application of simultaneous Equation Method for the Determination of Azithromycin and Cefixime Trihydrate in Tablet Formulation.Research Journal of Pharmacy and Technology.2017; 10(1):108-112.
ISSN:0974-4169
0974-4150
DOI:10.5958/0974-4150.2018.00124.4