The Impact of Serum Leptin, Leptin Receptor and Insulin on Maternal Obesity

[...]both of LEP and insulin are the strongest predictor for maternal BMI after age adjustment, while among overweight/obese females, LEPR has greatest impact on maternal obesity and insulin comes in second place. Taken together, all the participants had normal TC, LDL-C, while normal HDL-C was obse...

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Bibliographic Details
Published in:Research journal of pharmacy and technology 2019-07, Vol.12 (7), p.3569-3574
Main Authors: Al-Ogaidi, Shahla O., Abdulsattar, Sura A., Al-Dulaimi, Hameed M. J.
Format: Article
Language:English
Subjects:
Body mass index
Hormones
Insulin resistance
Lipids
Metabolic disorders
Obesity
Womens health
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Summary:[...]both of LEP and insulin are the strongest predictor for maternal BMI after age adjustment, while among overweight/obese females, LEPR has greatest impact on maternal obesity and insulin comes in second place. Taken together, all the participants had normal TC, LDL-C, while normal HDL-C was observed only in control group within the National Cholesterol Education Program (NCEP) reference ranges26. Since dyslipidemia is an abnormal lipid metabolism21 and defined by presence of one or more abnormal concentration of serum lipid biomarker, obese females with hypertriglyceridemia (hyper-TG) are considered dyslipidemic subjects26. The majority of studies have used HOMA-IR cut-off of 2.6 as an indicator of IR22. [...]obese females of current study are considered as insulin resistant. [...]Ben Slama et al. found that circulating LEP levels significantly increased with obesity compared to those controls30. [...]these results are inconsistent with previous findings that LEPR levels are significantly decreased, whereas LEP levels are significantly increased in morbidly obese subjects compared with lean individuals31.
ISSN:0974-3618
0974-360X
0974-306X
DOI:10.5958/0974-360X.2019.00609.7