Roles of miR-200 family members in lung cancer: more than tumor suppressors

miRNAs are a class of single-stranded noncoding RNAs, which have no coding potential, but modulate many molecular mechanisms including cancer pathogenesis. miRNAs participate in cell proliferation, differentiation, apoptosis, as well as carcinogenesis or cancer progression, and their involvement in...

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Bibliographic Details
Published in:Future oncology (London, England) England), 2018-11, Vol.14 (27), p.2875-2886
Main Authors: Liu, Cong, Hu, Wei, Li, Lin-Lin, Wang, Yu-Xuan, Zhou, Qun, Zhang, Feng, Song-Yang, Yi-Yan, Zhu, Wei, Sun, Cheng-Chao, Li, De-Jia
Format: Article
Language:English
Subjects:
Apoptosis
Apoptosis - genetics
Binding sites
Biomarkers
Carcinoma, Non-Small-Cell Lung - genetics
Carcinoma, Non-Small-Cell Lung - pathology
Cell Differentiation - genetics
Cell Proliferation - genetics
Disease Progression
drug resistance
EMT
Epigenesis, Genetic
epigenetic regulation
Epithelial-Mesenchymal Transition - genetics
Gene expression
Gene Expression Regulation, Neoplastic
Genes, Tumor Suppressor
Humans
Lung cancer
Lung Neoplasms - genetics
Lung Neoplasms - pathology
Medical prognosis
Medical screening
Metastasis
MicroRNAs
MicroRNAs - genetics
MicroRNAs - metabolism
miR-200s
miRNAs
NSCLC
radiosensitivity
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Summary:miRNAs are a class of single-stranded noncoding RNAs, which have no coding potential, but modulate many molecular mechanisms including cancer pathogenesis. miRNAs participate in cell proliferation, differentiation, apoptosis, as well as carcinogenesis or cancer progression, and their involvement in lung cancer has been recently shown. They are suggested to have bidirectional functions on important cancer-related genes so as to enhance or attenuate tumor genesis. Epithelial-mesenchymal transition (EMT) is a fundamental process which contributes to integrity of organogenesis and tissue differentiation as well as tissue repair, organ fibrosis and the progression of carcinoma, and several miRNAs were suggested to form the network regulating EMT in lung cancer, among which, miR-200 family members (miR-200a, miR-200b, miR-200c, miR-429 and miR-141) play crucial roles in the suppression of EMT. The function of the miR-200 family in lung carcinoma initiation and progression has been clarified in recent years, but at the same time some debates about their exact functional roles appeared. In this review, we will make a summary of recent studies about the unusual functions and mechanisms of miR-200 family in lung cancer.
ISSN:1479-6694
1744-8301
DOI:10.2217/fon-2018-0155