LOMG TERM EVALUATION OF A NOVEL TISSUE-ENGINEERED HEART VALVE WITHOUT ANY FOREIGN MATERIALS

We are developing a novel autologous tissue-engineered heart valve with a unique in-body tissue engineering. This is expected to be a viable bioprosthesis with better biocompatibility. In this study, we developed a conduit-type valve without any foreign materials and tested the feasibility and long-...

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Bibliographic Details
Published in:International journal of artificial organs 2019-08, Vol.42 (8)
Main Authors: Takewa, Y, Nakayama, Y, Shimamura, J, Katagiri, N, Tatsumi, E
Format: Article
Language:English
Subjects:
Aorta
Biocompatibility
Connective tissues
Endothelium
Feasibility studies
Fibroblasts
Goats
Heart valves
Implantation
Molds
Pulmonary arteries
Pulmonary artery
Regurgitation
Three dimensional printing
Tissue engineering
Valve leaflets
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Summary:We are developing a novel autologous tissue-engineered heart valve with a unique in-body tissue engineering. This is expected to be a viable bioprosthesis with better biocompatibility. In this study, we developed a conduit-type valve without any foreign materials and tested the feasibility and long-term availability in large animal experiments. We created plastic molds for Biovalves with a 3D printer easily and quickly considering the recipient character. We embedded them in the subcutaneous spaces of adult goats for about 2 months. After extracting the molds with the tissue en-block and removing the plastic molds only, Biovalves with tri-leaflets similar to those of the native valves were constituted from completely autologous connective tissues and fibroblasts. Total 21 conduit-type Biovalves were implanted in the apico-aortic bypass or the pulmonary artery of goats, (8 and 13, respectively). No anticoagurants were used after implantation. The valves were successfully implanted and showed smooth movement of the leaflets with a little regurgitation in angiogram, and the maximum duration reached to 3 years 7 months. Histological examination of the Biovalves showed the autologous cells covering the laminar surface of the valve leaflets as the endothelium and also migrating into the leaflet body to construct characteristic tissues like native leaflets. The valves have a potential to be used for viable bioprosthetic valves and to keep better function and biocompatibility longer than current ones.
ISSN:0391-3988
1724-6040