X‐ray crystal of diprotonated tetra‐(2‐pyridyl)pyrazine (H2TPPZ), aqua Fe3+‐phen crystal and new lanthanide complexes of TPPZ and their biochemical studies

• Published in: Applied organometallic chemistry 2019-09, Vol.33 (9), p.n/a
• Main Authors: Al‐Assy, Waleed H., Mohamed, Mahmoud M.A., Husein, Dalal Z., Mostafa, Mohsen M.
• Format: Article
• Language: English
• Subjects: 2,3,5,6‐tetrakis(2‐pyridyl)pyrazine (TPPZ); Anticancer properties; anticancer studies; Aqua‐Phen Fe(III) crystal; Au3+ single crystal; Bimetals; Chemistry; Chloroform; Coordination compounds; Crystals; Fungicides; IR and 1H‐NMR spectra; Lanthanides; Polyazines
• ISSN: 0268-2605; 1099-0739
• DOI: 10.1002/aoc.5106

New complexes derived from M3+ salts with polyazine as monometallic such as [Fe (TPPZ)Cl3].½H2O (1), [Cr (TPPZ)2Cl2]Cl.2EtOH (2), [La (TPPZ)(NO3)2(H2O)2]NO3.H2O (3) in addition to [Fe (Phen)3]3Cl.7H2O (4) were isolated. Three bimetallic, [H2TPPZ][(AuCl4)2]. H2O (5), [Ce2(TPPZ)EtOH (NO3)3]3NO3 (6) and [Nd2TPPZCl2(H2O)4]4Cl.CHCl3. 4H2O (7) and mixed ligand complexes, [Fe (TPPZ)(Phen)2]Cl3 (8), [Fe (TPPZ) (Phen)2][TPPZCl3] (9), [La2(TPPZ)(Phen)2(EtOH)2]6Cl.CHCl3.EtOH.H2O (10) and [Nd2(TPPZ)(Phen)Cl4]2Cl.3H2O (11) were synthesized and characterized. Crystal data of (4) is tetragonal, I41/a, a = b 35.951 (3) Å, c = 11.9055 (8) Å, α = 80.201 (2)° β = 78.846 (2)°, γ = 89.687 (2)° V = 741.06 (5)Å3, Z = 1 while triclinic, P1, a = 7.3913 (3) Å, b = 9.7344 (4) Å, c = 10.6577 (4) Å, α = β = γ = 90°, V = 741.06 (5)Å3 and Z = 170 for (5). Analyses, spectral and cyclic voltammetry studies indicate the bonding and the redox properties. Anticancer studies promised to be effective in lanthanides and some complexes were screened against antibacterial or antifungal. M(III) complexes derived from polyazine as monometallic as well as three bimetallic and mixed ligand complexes were synthesized and characterized. Biological studies were tested giving promised results.