Enantioselective Synthesis of 2‐Hydroxyalkyl Diarylphosphinates by Ruthenium‐Catalyzed Asymmetric Transfer Hydrogenation

An asymmetric transfer hydrogenation of 2‐oxo alkyl phosphinates in the presence of a chiral diamine ruthenium catalyst with HCOONa as a hydrogen source in aqueous 2,2,2‐trifluoroethanol under mild conditions gave a wide range of chiral 2‐hydroxyalkyl diarylphosphinates in enantiomeric excesses of 9...

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2019-09, Vol.361 (17), p.4106-4110
Main Authors: Zhang, Kaili, Yang, Yuping, Liu, Huan, Liu, Qixing, Lv, Jinliang, Zhou, Haifeng
Format: Article
Language:English
Subjects:
2-hydroxyalkyl diarylphosphinates
asymmetric transfer hydrogenation
Asymmetry
Enantiomers
Hydrogen storage
Hydrogenation
Noyori's catalysts
Ruthenium
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Summary:An asymmetric transfer hydrogenation of 2‐oxo alkyl phosphinates in the presence of a chiral diamine ruthenium catalyst with HCOONa as a hydrogen source in aqueous 2,2,2‐trifluoroethanol under mild conditions gave a wide range of chiral 2‐hydroxyalkyl diarylphosphinates in enantiomeric excesses of 97–99% and in good yields. The absolute configuration of the products was determined to be R by single‐crystal X‐ray diffraction.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201900569