Bovine colostrum in the treatment of acute diarrhea in Egyptian children: a randomised double-blinded, placebo-controlled trial

Background: Current therapies for the treatment of acute diarrhea in children focus primarily on oral rehydration therapy. However, this does not shorten the duration of diarrheal episodes, nor fasten healing of inflamed intestinal mucosa. Nutritional-based interventions offer a novel therapeutic al...

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Bibliographic Details
Published in:Pediatrics (Evanston) 2019-08, Vol.144 (2_MeetingAbstract), p.235-235
Main Authors: Barakat, Sana H M., Omar, Omnia, Meheissen, Marwa
Format: Article
Language:English
Subjects:
Antibiotics
Breast feeding
Breast milk
Children
Clinical trials
Colostrum
Dehydration
Diarrhea
Dysentery
Fever
Infections
Inflammation
Intestine
Malnutrition
Mucosa
Pediatrics
Population studies
Rehydration
Viruses
Vomiting
Waterborne diseases
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Summary:Background: Current therapies for the treatment of acute diarrhea in children focus primarily on oral rehydration therapy. However, this does not shorten the duration of diarrheal episodes, nor fasten healing of inflamed intestinal mucosa. Nutritional-based interventions offer a novel therapeutic alternative for acute diarrhea. Breast milk contains both pathogen-specific antibodies and numerous compounds that help intestinal healing, that's why breastfeeding during diarrheal illness is strongly encouraged by the WHO. One strategy to mimic its beneficial role is the use of bovine colostrum (BC). Objective:the aim of the present study was to evaluate the therapeutic efficacy of BC in acute diarrhea in children. Methods:This prospective interventional randomized clinical trial (RCT) was conducted on 160 children, aged 6 months to two years, with acute diarrhea for less than 48 hours, 80 cases were randomly treated with standard therapy of acute diarrhea plus BC 1 sachet/ day (3g) for 1 week (ImmuGuard®) (BC group) and 80 cases randomly received standard therapy of acute diarrhea plus placebo (placebo group). Children with diarrhea more than 48 hours, dysentery, other systemic infections, malnutrition or who received prior antibiotic or antidiarrheal treatment were excluded from the study. The two groups were comparable at entery regarding the frequency and duration of diarrhea and vomiting, fever, the degree of dehydration and initial Vesikari scoring. Results:.After 48 hours of treatment, the median stool frequency decreased from 7 stools per day to 2.5 in BC group and to 3 in placebo group (p
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.144.2MA3.235