Relationship between post-mortem interval and creatine concentration in vitreous humour and cerebrospinal fluid

Many chemical-based methods have been examined for determination of the post-mortem interval (PMI) using body fluid. However, creatine, a non-protein nitrogen, has hardly been investigated over the last 20 years, even though the possibility of using it for PMI determination has been reported. The ai...

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Bibliographic Details
Published in:Australian journal of forensic sciences 2014-04, Vol.46 (2), p.160-165
Main Authors: Takata, Tomoyo, Kitao, Takashi, Miyaishi, Satoru
Format: Article
Language:English
Subjects:
Body fluids
Brain
Cerebrospinal fluid
Correlation
Creatine
FORENSIC SCIENCE
Forensic sciences
Human remains
Nitrogen
Organic chemistry
post-mortem interval
Vitreous humour
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Summary:Many chemical-based methods have been examined for determination of the post-mortem interval (PMI) using body fluid. However, creatine, a non-protein nitrogen, has hardly been investigated over the last 20 years, even though the possibility of using it for PMI determination has been reported. The aim of the present study was to assess if creatine in vitreous humour and cerebrospinal fluid (CSF) correlates with PMI. Fifty-one subjects underwent vitreous humour and 56 subjects underwent CSF creatine measurement, respectively. The results showed that the creatine concentration increased linearly in the CSF and vitreous humour until about 50 and 90 hours after death, respectively. In particular, the creatine concentration in CSF (Pearson correlation = 0.79, p < 0.01) until 50 hours post-mortem was more strongly correlated with PMI than that in vitreous humour (Pearson correlation = 0.55, p < 0.01). Regarding the vitreous humour creatine concentration and PMI, our results showed a broad range at 24 hours post-mortem.
ISSN:0045-0618
1834-562X
DOI:10.1080/00450618.2013.824027