Severe quetiapine voluntary overdose successfully treated with a new hemoperfusion sorbent

Quetiapine overdose, although rare, is mainly linked with tachycardia, QTc-interval prolongation, somnolence, coma, hyperglycemia, and eventually hepatotoxicity and myocarditis. Extracorporeal techniques for quetiapine removal might be helpful, but only a few cases are reported in the literature. We...

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Bibliographic Details
Published in:International journal of artificial organs 2019-09, Vol.42 (9), p.516-520
Main Authors: Giuntoli, Lorenzo, Dalmastri, Vittorio, Cilloni, Nicola, Orsi, Claudio, Stalteri, Lucia, Demelas, Valentina, Giuliani, Giovanni, Gordini, Giovanni, De Ponti, Fabrizio, La Manna, Gaetano
Format: Article
Language:English
Subjects:
Adult
Antipsychotic Agents - adverse effects
Antipsychotic Agents - blood
Coma
Drug Overdose
Female
Heart diseases
Hemoperfusion
Hepatotoxicity
Humans
Hyperglycemia
Intensive Care Units
Myocarditis
Overdose
Prolongation
Quetiapine
Quetiapine Fumarate - adverse effects
Quetiapine Fumarate - blood
Renal Replacement Therapy
Sorbents
Sorption Detoxification - methods
Suicide, Attempted
Tachycardia
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Summary:Quetiapine overdose, although rare, is mainly linked with tachycardia, QTc-interval prolongation, somnolence, coma, hyperglycemia, and eventually hepatotoxicity and myocarditis. Extracorporeal techniques for quetiapine removal might be helpful, but only a few cases are reported in the literature. We here describe the case of a 27-year-old healthy woman, admitted to our Intensive Care Unit after voluntary quetiapine intake and successfully treated with CytoSorb hemoperfusion in combination with continuous renal replacement therapy (CRRT), in order to accelerate quetiapine elimination. This is the first published experience about the potential application of hemoadsorption therapies, as CytoSorb sorbent, in large overdoses of quetiapine and this approach might be feasible to rapidly remove the substance from blood, stabilizing the patient condition.
ISSN:0391-3988
1724-6040
DOI:10.1177/0391398819837686