Computed tomography‐guided intraluminal brachytherapy in recurrent bronchogenic carcinoma: A clinical trial in a small group

• Published in: Precision radiation oncology 2017-06, Vol.1 (2), p.52-57
• Main Authors: Ma, Chenying, Xu, Xiaoting, Zhang, Ruting, Qin, Songbing, Zhou, Juying
• Format: Article
• Language: English
• Subjects: Airway management; Cancer therapies; Chemotherapy; Clinical trials; Cryotherapy; Dyspnea; external beam radiation therapy; high‐dose rate; Injuries; intraluminal brachytherapy; Lung cancer; lung neoplasms; palliative care; Patients; Quality of life; Radiation therapy; Studies; Surgery; Tumors
• ISSN: 2398-7324; 2398-7324
• DOI: 10.1002/pro6.18

Objective The overall survival (OS) of lung cancer patients has been significantly extended as a consequence of chemotherapy and targeted drug utilization, which has resulted in an increase in local recurrences. The present study followed patients to evaluate the short‐term and long‐term efficacies and the safety of high‐dose rate intraluminal brachytherapy (ILBT) in recurrent bronchogenic carcinoma patients, and investigate the factors that influence prognosis. Methods The clinical records, treatment, curable effects, and adverse events of 15 patients treated in the First Affiliated Hospital of Soochow University, Suzhou, China, who were diagnosed with recurrent bronchogenic cancer between 1 June 2009 and 30 September 2015 were reviewed, and survival analysis was assessed by the Kaplan–Meier method. Results A total of 15 recurrent bronchogenic carcinoma patients received ILBT, and information on curable effects and safety was available. The group consisted of two complete response (2/15), 11 partial response (11/15), one stable disease (1/15) and one progression disease (1/15). The response rate was 86.7% (13/15), and disease control (complete response + partial response + stable disease) was 93.3% (14/15). The dyspnea indexes of the patients decreased significantly in weeks 1, 2, 4, and 8 after ILBT treatment (P