Distribution of two types of mast cells in the nasal mucosa after chemosurgical treatment of allergic rhinitis using trichloroacetic acid

To evaluate the efficacy of chemosurgery using trichloroacetic acid (TCA) for allergic rhinitis, two types of tissue mast cells [tryptase-positive, chymase-negative mast cells (MCT) and tryptase-positive, chymase-positive mast cells (MCTC)] in the nasal turbinate mucosa were immunohistochemically id...

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Bibliographic Details
Published in:American journal of rhinology 1999-03, Vol.13 (2), p.141-144
Main Authors: Yao, K, Suzuki, T, Iguchi, Y, Nishiyama, K, Yamamoto, K, Okamoto, M
Format: Article
Language:English
Subjects:
Administration, Topical
Adult
Caustics - administration & dosage
Cell Count
Female
Follow-Up Studies
Humans
Male
Mast Cells - immunology
Middle Aged
Nasal Mucosa - drug effects
Nasal Mucosa - immunology
Rhinitis, Allergic, Perennial - drug therapy
Rhinitis, Allergic, Perennial - immunology
Treatment Outcome
Trichloroacetic Acid - administration & dosage
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Summary:To evaluate the efficacy of chemosurgery using trichloroacetic acid (TCA) for allergic rhinitis, two types of tissue mast cells [tryptase-positive, chymase-negative mast cells (MCT) and tryptase-positive, chymase-positive mast cells (MCTC)] in the nasal turbinate mucosa were immunohistochemically identified and their distribution was assessed in clinical cases of patients who underwent unilateral TCA treatment. A comparison of the number of MCT and MCTC between the treated and nontreated sides indicates that both types of mast cells are significantly decreased in number in the treated side both in epithelial and lamina propria layers. The results indicate that TCA treatment was effective in suppressing MCT infiltration, regarded as a major cause of antigen-dependent allergy.
ISSN:1050-6586
1945-8924
1539-6290
1945-8932
DOI:10.2500/105065899782106733