Defect‐Rich Adhesive Nanozymes as Efficient Antibiotics for Enhanced Bacterial Inhibition

Nanozymes have emerged as a new generation of antibiotics with exciting broad‐spectrum antimicrobial properties and negligible biotoxicities. However, their antibacterial efficacies are unsatisfactory due to their inability to trap bacteria and their low catalytic activity. Herein, we report nanozym...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2019-11, Vol.58 (45), p.16236-16242
Main Authors: Cao, Fangfang, Zhang, Lu, Wang, Huan, You, Yawen, Wang, Ying, Gao, Nan, Ren, Jinsong, Qu, Xiaogang
Format: Article
Language:English
Subjects:
Antibiotics
Bacteria
Catalytic activity
cell adhesion
Defects
E coli
Excitation spectra
Exothermic reactions
Hydrogen peroxide
nanozymes
Peroxidase
reactive oxygen species
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Summary:Nanozymes have emerged as a new generation of antibiotics with exciting broad‐spectrum antimicrobial properties and negligible biotoxicities. However, their antibacterial efficacies are unsatisfactory due to their inability to trap bacteria and their low catalytic activity. Herein, we report nanozymes with rough surfaces and defect‐rich active edges. The rough surface increases bacterial adhesion and the defect‐rich edges exhibit higher intrinsic peroxidase‐like activity compared to pristine nanozymes due to their lower adsorption energies of H2O2 and desorption energy of OH*, as well as the larger exothermic process for the whole reaction. This was demonstrated using drug‐resistant Gram‐negative Escherichia coli and Gram‐positive Staphylococcus aureus in vitro and in vivo. This strategy can be used to engineer nanozymes with enhanced antibacterial function and will pave a new way for the development of alternative antibiotics. Defect‐rich, adhesive nanozymes: A rough surface endows nanozymes with the ability to trap bacteria and defect‐rich edges enhance their peroxidase‐like activity, increasing antibacterial activity in comparison to pristine nanozymes.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201908289