Predictors of uptake of contralateral prophylactic mastectomy in women with nonhereditary breast cancer

Background The rates of contralateral prophylactic mastectomy (CPM) are increasing in women with breast cancer. Previous retrospective research has examined clinical and demographic predictors of the uptake of CPM. However, to the authors' knowledge, there has been very little prospective resea...

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Bibliographic Details
Published in:Cancer 2019-11, Vol.125 (22), p.3966-3973
Main Authors: Metcalfe, Kelly A., Retrouvey, Helene, Kerrebijn, Isabel, Butler, Kate, O’Neill, Anne C., Cil, Tulin, Zhong, Toni, Hofer, Stefan O. P., McCready, David R.
Format: Article
Language:English
Subjects:
Anxiety
Body image
BRCA1 protein
BRCA2 protein
Breast cancer
Breast Neoplasms - epidemiology
Breast Neoplasms - etiology
Breast Neoplasms - prevention & control
Breast Neoplasms - surgery
Cancer surgery
contralateral prophylactic mastectomy
Decision making
Demographics
Depression
Female
Genes, BRCA1
Genes, BRCA2
Humans
Invasiveness
Mastectomy
Middle Aged
Mutation
Neoplasm Staging
Oncology
Ontario - epidemiology
Optimism
predictors
Prognosis
Prophylactic Mastectomy
psychosocial
Public Health Surveillance
Quality of life
Questionnaires
Social interactions
Surgery
Surveys and Questionnaires
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Summary:Background The rates of contralateral prophylactic mastectomy (CPM) are increasing in women with breast cancer. Previous retrospective research has examined clinical and demographic predictors of the uptake of CPM. However, to the authors' knowledge, there has been very little prospective research to date that has examined psychosocial functioning prior to breast cancer surgery to determine whether psychosocial functioning predicts uptake of CPM. The current study was conducted to evaluate demographic, clinical, and psychosocial predictors of the uptake of CPM in women with unilateral breast cancer without a BRCA1 or BRCA2 mutation. Methods Women with unilateral non–BRCA‐associated breast cancer completed questionnaires prior to undergoing breast cancer surgery. Participants completed demographic and psychosocial questionnaires assessing anxiety, depression, cancer‐related distress, optimism/pessimism, breast satisfaction, and quality of life. Pathological and surgical data were collected from medical charts. Results A total of 506 women consented to participate, 112 of whom (22.1%) elected to undergo CPM. Age was found to be a significant predictor of CPM, with younger women found to be significantly more likely to undergo CPM compared with older women (P 
ISSN:0008-543X
1097-0142
DOI:10.1002/cncr.32405