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Predictors of uptake of contralateral prophylactic mastectomy in women with nonhereditary breast cancer
Background The rates of contralateral prophylactic mastectomy (CPM) are increasing in women with breast cancer. Previous retrospective research has examined clinical and demographic predictors of the uptake of CPM. However, to the authors' knowledge, there has been very little prospective resea...
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| Published in: | Cancer 2019-11, Vol.125 (22), p.3966-3973 |
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| container_end_page | 3973 |
| container_issue | 22 |
| container_start_page | 3966 |
| container_title | Cancer |
| container_volume | 125 |
| creator | Metcalfe, Kelly A. Retrouvey, Helene Kerrebijn, Isabel Butler, Kate O’Neill, Anne C. Cil, Tulin Zhong, Toni Hofer, Stefan O. P. McCready, David R. |
| description | Background
The rates of contralateral prophylactic mastectomy (CPM) are increasing in women with breast cancer. Previous retrospective research has examined clinical and demographic predictors of the uptake of CPM. However, to the authors' knowledge, there has been very little prospective research to date that has examined psychosocial functioning prior to breast cancer surgery to determine whether psychosocial functioning predicts uptake of CPM. The current study was conducted to evaluate demographic, clinical, and psychosocial predictors of the uptake of CPM in women with unilateral breast cancer without a BRCA1 or BRCA2 mutation.
Methods
Women with unilateral non–BRCA‐associated breast cancer completed questionnaires prior to undergoing breast cancer surgery. Participants completed demographic and psychosocial questionnaires assessing anxiety, depression, cancer‐related distress, optimism/pessimism, breast satisfaction, and quality of life. Pathological and surgical data were collected from medical charts.
Results
A total of 506 women consented to participate, 112 of whom (22.1%) elected to undergo CPM. Age was found to be a significant predictor of CPM, with younger women found to be significantly more likely to undergo CPM compared with older women (P |
| doi_str_mv | 10.1002/cncr.32405 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2309922262</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2309922262</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3935-542b44f03a0e18b425c02458a6a0436f4c32f89f65178d1075472be06c5860b13</originalsourceid><addsrcrecordid>eNp9kMtKxDAUhoMozji68QEk4E7oeHLrZSnFG4iKKLgraSZ1OvZmkjL07U3t6NLNSQJfvvPzI3RKYEkA6KVqlFkyykHsoTmBJAqAcLqP5gAQB4Kz9xk6snbjnxEV7BDNGOFMJCyZo49no1elcq2xuC1w3zn5qcebahtnZCWd9hN3pu3WQyWVKxWupXXaf6kHXDZ429baz9KtcdM2az36nDQDzo32IFayUdoco4NCVlaf7M4Feru5fk3vgoen2_v06iFQLGHCh6U55wUwCZrEOadCAeUilqEEzsKCK0aLOClCQaJ4RSASPKK5hlCJOIScsAU6n7w-8Vevrcs2bW8avzKjDJKEUhpST11MlDKttUYXWWfK2ofOCGRjp9nYafbTqYfPdso-r_XqD_0t0QNkArZlpYd_VFn6mL5M0m_KloHI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2309922262</pqid></control><display><type>article</type><title>Predictors of uptake of contralateral prophylactic mastectomy in women with nonhereditary breast cancer</title><source>Wiley-Blackwell Read & Publish Collection</source><source>EZB Electronic Journals Library</source><creator>Metcalfe, Kelly A. ; Retrouvey, Helene ; Kerrebijn, Isabel ; Butler, Kate ; O’Neill, Anne C. ; Cil, Tulin ; Zhong, Toni ; Hofer, Stefan O. P. ; McCready, David R.</creator><creatorcontrib>Metcalfe, Kelly A. ; Retrouvey, Helene ; Kerrebijn, Isabel ; Butler, Kate ; O’Neill, Anne C. ; Cil, Tulin ; Zhong, Toni ; Hofer, Stefan O. P. ; McCready, David R.</creatorcontrib><description>Background
The rates of contralateral prophylactic mastectomy (CPM) are increasing in women with breast cancer. Previous retrospective research has examined clinical and demographic predictors of the uptake of CPM. However, to the authors' knowledge, there has been very little prospective research to date that has examined psychosocial functioning prior to breast cancer surgery to determine whether psychosocial functioning predicts uptake of CPM. The current study was conducted to evaluate demographic, clinical, and psychosocial predictors of the uptake of CPM in women with unilateral breast cancer without a BRCA1 or BRCA2 mutation.
Methods
Women with unilateral non–BRCA‐associated breast cancer completed questionnaires prior to undergoing breast cancer surgery. Participants completed demographic and psychosocial questionnaires assessing anxiety, depression, cancer‐related distress, optimism/pessimism, breast satisfaction, and quality of life. Pathological and surgical data were collected from medical charts.
Results
A total of 506 women consented to participate, 112 of whom (22.1%) elected to undergo CPM. Age was found to be a significant predictor of CPM, with younger women found to be significantly more likely to undergo CPM compared with older women (P < .0001). The rate of CPM was significantly higher in women with noninvasive breast cancer compared with those with invasive breast cancer (P < .0001). Women who elected to undergo CPM had lower levels of presurgical breast satisfaction (P = .01) and optimism (P = .05) compared with women who did not undergo CPM.
Conclusions
Psychosocial functioning at the time of breast cancer surgery decision making impacts decisions related to CPM. Women who have lower levels of breast satisfaction (body image) and optimism are more likely to elect to undergo CPM. It is important for health care providers to take psychosocial functioning into consideration when discussing surgical options.
Psychosocial functioning at the time of breast cancer surgery decision making impacts decisions related to contralateral prophylactic mastectomy. Therefore, it is important for health care providers to take psychosocial functioning into consideration when discussing surgical options with patients.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/cncr.32405</identifier><identifier>PMID: 31435939</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Anxiety ; Body image ; BRCA1 protein ; BRCA2 protein ; Breast cancer ; Breast Neoplasms - epidemiology ; Breast Neoplasms - etiology ; Breast Neoplasms - prevention & control ; Breast Neoplasms - surgery ; Cancer surgery ; contralateral prophylactic mastectomy ; Decision making ; Demographics ; Depression ; Female ; Genes, BRCA1 ; Genes, BRCA2 ; Humans ; Invasiveness ; Mastectomy ; Middle Aged ; Mutation ; Neoplasm Staging ; Oncology ; Ontario - epidemiology ; Optimism ; predictors ; Prognosis ; Prophylactic Mastectomy ; psychosocial ; Public Health Surveillance ; Quality of life ; Questionnaires ; Social interactions ; Surgery ; Surveys and Questionnaires</subject><ispartof>Cancer, 2019-11, Vol.125 (22), p.3966-3973</ispartof><rights>2019 American Cancer Society</rights><rights>2019 American Cancer Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3935-542b44f03a0e18b425c02458a6a0436f4c32f89f65178d1075472be06c5860b13</citedby><cites>FETCH-LOGICAL-c3935-542b44f03a0e18b425c02458a6a0436f4c32f89f65178d1075472be06c5860b13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31435939$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Metcalfe, Kelly A.</creatorcontrib><creatorcontrib>Retrouvey, Helene</creatorcontrib><creatorcontrib>Kerrebijn, Isabel</creatorcontrib><creatorcontrib>Butler, Kate</creatorcontrib><creatorcontrib>O’Neill, Anne C.</creatorcontrib><creatorcontrib>Cil, Tulin</creatorcontrib><creatorcontrib>Zhong, Toni</creatorcontrib><creatorcontrib>Hofer, Stefan O. P.</creatorcontrib><creatorcontrib>McCready, David R.</creatorcontrib><title>Predictors of uptake of contralateral prophylactic mastectomy in women with nonhereditary breast cancer</title><title>Cancer</title><addtitle>Cancer</addtitle><description>Background
The rates of contralateral prophylactic mastectomy (CPM) are increasing in women with breast cancer. Previous retrospective research has examined clinical and demographic predictors of the uptake of CPM. However, to the authors' knowledge, there has been very little prospective research to date that has examined psychosocial functioning prior to breast cancer surgery to determine whether psychosocial functioning predicts uptake of CPM. The current study was conducted to evaluate demographic, clinical, and psychosocial predictors of the uptake of CPM in women with unilateral breast cancer without a BRCA1 or BRCA2 mutation.
Methods
Women with unilateral non–BRCA‐associated breast cancer completed questionnaires prior to undergoing breast cancer surgery. Participants completed demographic and psychosocial questionnaires assessing anxiety, depression, cancer‐related distress, optimism/pessimism, breast satisfaction, and quality of life. Pathological and surgical data were collected from medical charts.
Results
A total of 506 women consented to participate, 112 of whom (22.1%) elected to undergo CPM. Age was found to be a significant predictor of CPM, with younger women found to be significantly more likely to undergo CPM compared with older women (P < .0001). The rate of CPM was significantly higher in women with noninvasive breast cancer compared with those with invasive breast cancer (P < .0001). Women who elected to undergo CPM had lower levels of presurgical breast satisfaction (P = .01) and optimism (P = .05) compared with women who did not undergo CPM.
Conclusions
Psychosocial functioning at the time of breast cancer surgery decision making impacts decisions related to CPM. Women who have lower levels of breast satisfaction (body image) and optimism are more likely to elect to undergo CPM. It is important for health care providers to take psychosocial functioning into consideration when discussing surgical options.
Psychosocial functioning at the time of breast cancer surgery decision making impacts decisions related to contralateral prophylactic mastectomy. Therefore, it is important for health care providers to take psychosocial functioning into consideration when discussing surgical options with patients.</description><subject>Anxiety</subject><subject>Body image</subject><subject>BRCA1 protein</subject><subject>BRCA2 protein</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - epidemiology</subject><subject>Breast Neoplasms - etiology</subject><subject>Breast Neoplasms - prevention & control</subject><subject>Breast Neoplasms - surgery</subject><subject>Cancer surgery</subject><subject>contralateral prophylactic mastectomy</subject><subject>Decision making</subject><subject>Demographics</subject><subject>Depression</subject><subject>Female</subject><subject>Genes, BRCA1</subject><subject>Genes, BRCA2</subject><subject>Humans</subject><subject>Invasiveness</subject><subject>Mastectomy</subject><subject>Middle Aged</subject><subject>Mutation</subject><subject>Neoplasm Staging</subject><subject>Oncology</subject><subject>Ontario - epidemiology</subject><subject>Optimism</subject><subject>predictors</subject><subject>Prognosis</subject><subject>Prophylactic Mastectomy</subject><subject>psychosocial</subject><subject>Public Health Surveillance</subject><subject>Quality of life</subject><subject>Questionnaires</subject><subject>Social interactions</subject><subject>Surgery</subject><subject>Surveys and Questionnaires</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kMtKxDAUhoMozji68QEk4E7oeHLrZSnFG4iKKLgraSZ1OvZmkjL07U3t6NLNSQJfvvPzI3RKYEkA6KVqlFkyykHsoTmBJAqAcLqP5gAQB4Kz9xk6snbjnxEV7BDNGOFMJCyZo49no1elcq2xuC1w3zn5qcebahtnZCWd9hN3pu3WQyWVKxWupXXaf6kHXDZ429baz9KtcdM2az36nDQDzo32IFayUdoco4NCVlaf7M4Feru5fk3vgoen2_v06iFQLGHCh6U55wUwCZrEOadCAeUilqEEzsKCK0aLOClCQaJ4RSASPKK5hlCJOIScsAU6n7w-8Vevrcs2bW8avzKjDJKEUhpST11MlDKttUYXWWfK2ofOCGRjp9nYafbTqYfPdso-r_XqD_0t0QNkArZlpYd_VFn6mL5M0m_KloHI</recordid><startdate>20191115</startdate><enddate>20191115</enddate><creator>Metcalfe, Kelly A.</creator><creator>Retrouvey, Helene</creator><creator>Kerrebijn, Isabel</creator><creator>Butler, Kate</creator><creator>O’Neill, Anne C.</creator><creator>Cil, Tulin</creator><creator>Zhong, Toni</creator><creator>Hofer, Stefan O. P.</creator><creator>McCready, David R.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope></search><sort><creationdate>20191115</creationdate><title>Predictors of uptake of contralateral prophylactic mastectomy in women with nonhereditary breast cancer</title><author>Metcalfe, Kelly A. ; Retrouvey, Helene ; Kerrebijn, Isabel ; Butler, Kate ; O’Neill, Anne C. ; Cil, Tulin ; Zhong, Toni ; Hofer, Stefan O. P. ; McCready, David R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3935-542b44f03a0e18b425c02458a6a0436f4c32f89f65178d1075472be06c5860b13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Anxiety</topic><topic>Body image</topic><topic>BRCA1 protein</topic><topic>BRCA2 protein</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - epidemiology</topic><topic>Breast Neoplasms - etiology</topic><topic>Breast Neoplasms - prevention & control</topic><topic>Breast Neoplasms - surgery</topic><topic>Cancer surgery</topic><topic>contralateral prophylactic mastectomy</topic><topic>Decision making</topic><topic>Demographics</topic><topic>Depression</topic><topic>Female</topic><topic>Genes, BRCA1</topic><topic>Genes, BRCA2</topic><topic>Humans</topic><topic>Invasiveness</topic><topic>Mastectomy</topic><topic>Middle Aged</topic><topic>Mutation</topic><topic>Neoplasm Staging</topic><topic>Oncology</topic><topic>Ontario - epidemiology</topic><topic>Optimism</topic><topic>predictors</topic><topic>Prognosis</topic><topic>Prophylactic Mastectomy</topic><topic>psychosocial</topic><topic>Public Health Surveillance</topic><topic>Quality of life</topic><topic>Questionnaires</topic><topic>Social interactions</topic><topic>Surgery</topic><topic>Surveys and Questionnaires</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Metcalfe, Kelly A.</creatorcontrib><creatorcontrib>Retrouvey, Helene</creatorcontrib><creatorcontrib>Kerrebijn, Isabel</creatorcontrib><creatorcontrib>Butler, Kate</creatorcontrib><creatorcontrib>O’Neill, Anne C.</creatorcontrib><creatorcontrib>Cil, Tulin</creatorcontrib><creatorcontrib>Zhong, Toni</creatorcontrib><creatorcontrib>Hofer, Stefan O. P.</creatorcontrib><creatorcontrib>McCready, David R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Metcalfe, Kelly A.</au><au>Retrouvey, Helene</au><au>Kerrebijn, Isabel</au><au>Butler, Kate</au><au>O’Neill, Anne C.</au><au>Cil, Tulin</au><au>Zhong, Toni</au><au>Hofer, Stefan O. P.</au><au>McCready, David R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predictors of uptake of contralateral prophylactic mastectomy in women with nonhereditary breast cancer</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>2019-11-15</date><risdate>2019</risdate><volume>125</volume><issue>22</issue><spage>3966</spage><epage>3973</epage><pages>3966-3973</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><abstract>Background
The rates of contralateral prophylactic mastectomy (CPM) are increasing in women with breast cancer. Previous retrospective research has examined clinical and demographic predictors of the uptake of CPM. However, to the authors' knowledge, there has been very little prospective research to date that has examined psychosocial functioning prior to breast cancer surgery to determine whether psychosocial functioning predicts uptake of CPM. The current study was conducted to evaluate demographic, clinical, and psychosocial predictors of the uptake of CPM in women with unilateral breast cancer without a BRCA1 or BRCA2 mutation.
Methods
Women with unilateral non–BRCA‐associated breast cancer completed questionnaires prior to undergoing breast cancer surgery. Participants completed demographic and psychosocial questionnaires assessing anxiety, depression, cancer‐related distress, optimism/pessimism, breast satisfaction, and quality of life. Pathological and surgical data were collected from medical charts.
Results
A total of 506 women consented to participate, 112 of whom (22.1%) elected to undergo CPM. Age was found to be a significant predictor of CPM, with younger women found to be significantly more likely to undergo CPM compared with older women (P < .0001). The rate of CPM was significantly higher in women with noninvasive breast cancer compared with those with invasive breast cancer (P < .0001). Women who elected to undergo CPM had lower levels of presurgical breast satisfaction (P = .01) and optimism (P = .05) compared with women who did not undergo CPM.
Conclusions
Psychosocial functioning at the time of breast cancer surgery decision making impacts decisions related to CPM. Women who have lower levels of breast satisfaction (body image) and optimism are more likely to elect to undergo CPM. It is important for health care providers to take psychosocial functioning into consideration when discussing surgical options.
Psychosocial functioning at the time of breast cancer surgery decision making impacts decisions related to contralateral prophylactic mastectomy. Therefore, it is important for health care providers to take psychosocial functioning into consideration when discussing surgical options with patients.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>31435939</pmid><doi>10.1002/cncr.32405</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | Wiley-Blackwell Read & Publish Collection; EZB Electronic Journals Library |
| subjects | Anxiety Body image BRCA1 protein BRCA2 protein Breast cancer Breast Neoplasms - epidemiology Breast Neoplasms - etiology Breast Neoplasms - prevention & control Breast Neoplasms - surgery Cancer surgery contralateral prophylactic mastectomy Decision making Demographics Depression Female Genes, BRCA1 Genes, BRCA2 Humans Invasiveness Mastectomy Middle Aged Mutation Neoplasm Staging Oncology Ontario - epidemiology Optimism predictors Prognosis Prophylactic Mastectomy psychosocial Public Health Surveillance Quality of life Questionnaires Social interactions Surgery Surveys and Questionnaires |
| title | Predictors of uptake of contralateral prophylactic mastectomy in women with nonhereditary breast cancer |
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