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Retracted: Combined Photoredox/Enzymatic C−H Benzylic Hydroxylations

Chemical transformations that install heteroatoms into C−H bonds are of significant interest because they streamline the construction of value‐added small molecules. Direct C−H oxyfunctionalization, or the one step conversion of a C−H bond to a C−O bond, could be a highly enabling transformation due...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2019-11, Vol.58 (46), p.16490-16494
Main Authors: Betori, Rick C., May, Catherine M., Scheidt, Karl A.
Format: Article
Language:English
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Summary:Chemical transformations that install heteroatoms into C−H bonds are of significant interest because they streamline the construction of value‐added small molecules. Direct C−H oxyfunctionalization, or the one step conversion of a C−H bond to a C−O bond, could be a highly enabling transformation due to the prevalence of the resulting enantioenriched alcohols in pharmaceuticals and natural products,. Here we report a single‐flask photoredox/enzymatic process for direct C−H hydroxylation that proceeds with broad reactivity, chemoselectivity and enantioselectivity. This unified strategy advances general photoredox and enzymatic catalysis synergy and enables chemoenzymatic processes for powerful and selective oxidative transformations.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201909426