The evaluation of 2.3-diazepine influence on tissue respiration of the liver and its exocrine function in rats with a rotenone model of Parkinson’s disease

Parkinson’s disease (PD) is a progressive neurodegenerative disorder, characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta. The causes of PD are not fully understood; however, increasing evidence implicates disturbed respiratory function of the mitochondria and a l...

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Bibliographic Details
Published in:Biopolimery i kletka 2019, Vol.35 (5), p.356-370
Main Authors: Khilya, V. P., Yanchuk, I. P., Shtanova, L. Ya, Veselsky, S. P., Vovkun, T. V., Tsymbalyuk, O. V., Moskvina, V. S., Shablykina, O. V., Bogza, S. L.
Format: Article
Language:English
Subjects:
Benzodiazepines
Bile
Bile acids
Bile ducts
Cholic acid
Dopamine receptors
Glycine
Liver
Mitochondria
Movement disorders
Neurodegenerative diseases
Oxygen consumption
Parenchyma
Parkinson's disease
Polyethylene
Respiration
Respiratory function
Rot
Rotenone
Substantia nigra
Taurine
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Summary:Parkinson’s disease (PD) is a progressive neurodegenerative disorder, characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta. The causes of PD are not fully understood; however, increasing evidence implicates disturbed respiratory function of the mitochondria and a lack of energy in cells. Aim. To study the effects of 2.3-diazepine (2.3-DP), a new derivative of benzodiazepine, on liver tissue respiration (LTR) and energy dependent processes of bile and bile acids (BAs) production in a rat model of PD. Methods. PD was induced by intraperitoneal injections of rotenone (ROT). LTR (the intensity of the oxygen uptake) was assessed using the polarograph LP-9 (Czech Republic). Secreted bile was collected during 1 hour of the experiment through the polyethylene catheter inserted into the common bile duct. BAs were separated by the method of thin layer chromatography. Results. ROT diminished the index of liver oxygen consumption by 34 % (p
ISSN:0233-7657
1993-6842
DOI:10.7124/bc.000A13