Less activation of the left dosolateral prefrontal cortex in response to a meal: a feature of obesity

Background: In an exploratory positron emission tomography study of postprandial regional cerebral blood flow, which is a marker of neuronal activity, obese men differed from lean men in several brain regions, including the prefrontal cortex. The subjects received a meal proportional to their body s...

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Bibliographic Details
Published in:The American journal of clinical nutrition 2006-10, Vol.84 (4), p.725
Main Authors: Duc Son NT Le, Pannacciulli, Nicola, Chen, Kewei, Angelo Del Parigi
Format: Article
Language:English
Subjects:
Cognition & reasoning
Diet
Men
Neurosciences
Obesity
Online Access:Get full text
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Summary:Background: In an exploratory positron emission tomography study of postprandial regional cerebral blood flow, which is a marker of neuronal activity, obese men differed from lean men in several brain regions, including the prefrontal cortex. The subjects received a meal proportional to their body size; therefore, the meal volume was different for each person. Objective: We investigated whether differences in the brain responses of obese and lean men to a meal represent satiety or feelings of gastric distension. Design: We studied 9 lean ( +/- SD body fat: 15 +/- 5%; age: 33 +/- 10 y) and 9 obese (body fat: 31 +/- 4%; age: 32 +/- 10 y) men given a fixed amount (400 mL) of a liquid meal. We compared their results with those in 11 lean (body fat: 16 +/- 5%; age: 35 +/- 8 y) and 11 obese (body fat: 33 +/- 5%; age: 28 +/- 5 y) previously studied men given a meal proportional to their body size. We performed analyses by using a two-level, random-effects approach in the STATISTICAL PARAMETRIC MAPPING software package and a significance level of P
ISSN:0002-9165
1938-3207