Glutamine-enriched enteral nutrition in very-low-birth-weight infants and effects on feeding tolerance and infectious morbidity: a randomized controlled trial

Background: Glutamine depletion has negative effects on the functional integrity of the gut and leads to immunosuppression. Very-low-birth-weight (VLBW) infants are susceptible to glutamine depletion because nutrition is limited in the first weeks of life. Objective: The objective was to determine t...

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Bibliographic Details
Published in:The American journal of clinical nutrition 2005-06, Vol.81 (6), p.1397-1404
Main Authors: Berg, A. van den, Elburg, R.M. van, Westerbeek, E.A.M, Twisk, J.W.R, Fetter, W.P.F
Format: Article
Language:English
Subjects:
Amino acids
Babies
Biological and medical sciences
Birth weight
Clinical trials
Dose-Response Relationship, Drug
Double-Blind Method
Enteral Nutrition
Feeding. Feeding behavior
Female
food tolerance
Fundamental and applied biological sciences. Psychology
glutamine
Glutamine - administration & dosage
high protein diet
Humans
Incidence
Infant
infant feeding
Infant Food
Infant Nutritional Physiological Phenomena
Infant, Newborn
Infant, Very Low Birth Weight - growth & development
infection
Infection Control
low birth weight
Male
Morbidity
Nutrition
premature birth
Sepsis - epidemiology
Sepsis - prevention & control
small for gestational age
Time Factors
Treatment Outcome
tube feeding
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:Background: Glutamine depletion has negative effects on the functional integrity of the gut and leads to immunosuppression. Very-low-birth-weight (VLBW) infants are susceptible to glutamine depletion because nutrition is limited in the first weeks of life. Objective: The objective was to determine the effect of glutamine-enriched enteral nutrition on feeding tolerance, infectious morbidity, and short-term outcome in VLBW infants. Design: In a double-blind randomized controlled trial, VLBW infants (gestational age
ISSN:0002-9165
1938-3207
DOI:10.1093/ajcn/81.6.1397