Pilot evaluation of hypnotic medication during acute traumatic stress response

Early intervention aimed at secondary prevention is a high priority for posttraumatic stress disorder (PTSD) research. Disrupted sleep may have a role in the initiation and maintenance of PTSD. Three of the participants were recruited from a surgical trauma service, and one had sought treatment in a...

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Bibliographic Details
Published in:Journal of traumatic stress 1998-07, Vol.11 (3), p.563-569
Main Authors: Mellman, Thomas A., Byers, Patricia M., Augenstein, Jeffrey S.
Format: Article
Language:English
Subjects:
acute
Acute Disease
Adolescent
Adult
Anti-Anxiety Agents - administration & dosage
Anti-Anxiety Agents - adverse effects
Arousal
Biological and medical sciences
Combined Modality Therapy
Crisis Intervention
Dose-Response Relationship, Drug
Drug Administration Schedule
Humans
hypnotic medication
Hypnotics and Sedatives - administration & dosage
Hypnotics and Sedatives - adverse effects
Hypnotics. Sedatives
Male
Medical sciences
Neuropharmacology
Personality Inventory
Pharmacology. Drug treatments
Pilot Projects
posttraumatic stress disorder
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
sleep
Sleep Initiation and Maintenance Disorders - diagnosis
Sleep Initiation and Maintenance Disorders - drug therapy
Sleep Initiation and Maintenance Disorders - psychology
Stress Disorders, Post-Traumatic - diagnosis
Stress Disorders, Post-Traumatic - drug therapy
Stress Disorders, Post-Traumatic - psychology
Temazepam - administration & dosage
Temazepam - adverse effects
Wounds and Injuries - psychology
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Summary:Early intervention aimed at secondary prevention is a high priority for posttraumatic stress disorder (PTSD) research. Disrupted sleep may have a role in the initiation and maintenance of PTSD. Three of the participants were recruited from a surgical trauma service, and one had sought treatment in a psychiatric setting. All were within 1‐3 weeks of trauma exposure and had acute PTSD symptoms that included disturbed sleep. Temazepam, a benzodiazepine hypnotic, was administered for 5 nights, tapered for 2 nights, and then discontinued. Evaluations 1‐week after the medication had been discontinued revealed improved sleep and reduced PTSD severity. These observations suggest an approach that may be clinically useful and a need for more systematic trials.
ISSN:0894-9867
1573-6598
DOI:10.1023/A:1024460814230