Product Composition, Structure, and Bioavailability

• Published in: Food biophysics 2008-06, Vol.3 (2), p.207-212
• Main Authors: Duchateau, Guus S. M. J. E, Klaffke, Werner
• Format: Article
• Language: English
• Subjects: Analytical Chemistry; Bioaccessibility; Bioavailability; Biological and Medical Physics; Biophysics; Chemistry; Chemistry and Materials Science; Food; Food products; Food Science; functional foods; Functional foods & nutraceuticals; Physicochemical properties; Physiology; Special Issue Article; Structure; Studies
• ISSN: 1557-1858; 1557-1866
• DOI: 10.1007/s11483-008-9076-5

Bioavailability is the fraction of an administered dose that reaches the systemic circulation. Health claims for functional foods can only be made if the ingredient reaches the target site to trigger the physiological action, hence substantiation requires good bioavailability. This is also expressed in the European Regulation on Health Claims. Albeit not new at all, a full understanding of the controlling factors for bioavailability in foods is still lacking. Foods are complex systems and can be part of a meal. The impact of product composition and the interplay with human physiology during fed or fasted state has to be understood: a functional ingredient has to be released from the product matrix into a molecularly dispersed state, either in classic solution or in micellar state. Only in the dispersed state can actives cross the gut wall. Release and dissolution are depending on both molecular physicochemical properties of the active and those of the entire product. More complex is the uptake of hydrophobic, poorly water-soluble substrates. As they do not dissolve in the aqueous intestinal environment, presence of fat, release of bile, enzymes, and gut motility to induce lipolysis are required. Surface-active bile salts together with lipolysis products create micelles containing the hydrophobic active. This imposes limitations on the formulation space for hydrophobic compounds. Finally, many ingredients are not fit for straightforward use as they compromise the stability or sensory characteristics of the product. Compartmentalization strategies, like encapsulation, may offer solutions to the problem; it should, however, not be forgotten that encapsulates themselves may effect bioavailability through the changed dynamics of the uptake processes. To explore and build a better understanding of these factors, a range of models are available and used in product formulation and claim substantiation. A structured approach and the selection of proper models will help to improve functional food formulations in the future.