Correlations Between Akathisia and Residual Psychopathology: A By-product of Neuroleptic-Induced Dysphoria

Patients developing neuroleptic-induced akathisia have been reported to show higher levels of psychopathology. We sought to replicate this finding and determine its symptom specificity. We confirmed a significant relationship between ratings of akathisia and total score on the Brief Psychiatric Rati...

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Bibliographic Details
Published in:British journal of psychiatry 1994-06, Vol.164 (6), p.834-838
Main Authors: Newcomer, John W., Miller, L. Stephen, Faustman, William O., Wetzel, Martin W., Vogler, George P., Csernansky, John G.
Format: Article
Language:English
Subjects:
Adult
Aged
Akathisia
Akathisia, Drug-Induced - psychology
Anxiety Disorders - chemically induced
Anxiety Disorders - psychology
Depressive Disorder - chemically induced
Depressive Disorder - psychology
Dose-Response Relationship, Drug
Haloperidol - administration & dosage
Haloperidol - adverse effects
Humans
Induced
Male
Mental depression
Middle Aged
Neurologic Examination - drug effects
Psychiatric Status Rating Scales
Psychopathology
Psychotic Disorders - drug therapy
Psychotic Disorders - psychology
Psychotropic drugs
Regression analysis
Schizophrenia - drug therapy
Schizophrenic Psychology
Short papers
Veterans - psychology
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Summary:Patients developing neuroleptic-induced akathisia have been reported to show higher levels of psychopathology. We sought to replicate this finding and determine its symptom specificity. We confirmed a significant relationship between ratings of akathisia and total score on the Brief Psychiatric Rating Scale (BPRS) during both acute and maintenance neuroleptic treatment. Using stepwise regression models, BPRS anxious-depressive subscale scores were the strongest predictors of akathisia during both treatment conditions. Paranoid subscale scores predicted akathisia only during maintenance treatment. These results suggest that neuroleptic-induced dysphoria largely explains the relationship between akathisia and residual psychopathology during both acute and maintenance neuroleptic treatment.
ISSN:0007-1250
1472-1465
DOI:10.1192/bjp.164.6.834