The enantioselective construction of trifluoromethylated quaternary stereocenters via the Rh-catalyzed asymmetric dehydrated arylation of unprotected hemiaminals

A method for the highly enantioselective Rh-catalyzed dehydrated arylation of unprotected hemiaminals has been developed, and provided a series of chiral benzosultams bearing trifluoromethylated quaternary stereocenters in high yields with excellent enantioselectivities (up to 99% ee). The synthetic...

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Bibliographic Details
Published in:Organic chemistry frontiers an international journal of organic chemistry 2020-01, Vol.7 (2), p.340-344
Main Authors: Yu-Tuo, Sun, Dong-Xing, Zhu, Rao, Xiaofeng, Ming-Hua, Xu
Format: Article
Language:English
Subjects:
Construction
Crystallography
Dehydration
Enantiomers
HIV
Human immunodeficiency virus
Organic chemistry
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Summary:A method for the highly enantioselective Rh-catalyzed dehydrated arylation of unprotected hemiaminals has been developed, and provided a series of chiral benzosultams bearing trifluoromethylated quaternary stereocenters in high yields with excellent enantioselectivities (up to 99% ee). The synthetic utility was further demonstrated by the facile enantioselective construction of a HIV-1 inhibitor molecule.
ISSN:2052-4110
2052-4110
DOI:10.1039/c9qo01203f