Diarrhea Associated with Lopinavir/Ritonavir-Based Therapy

BackgroundAntiretroviral therapy is associated with adverse events (AEs). The most frequently reported AE associated with lopinavir/ritonavir (LPV/r) containing regimens is diarrhea. The objective of this meta-analysis is to describe the incidence, prevalence, and duration of diarrhea in individuals...

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Bibliographic Details
Published in:Journal of the International Association of Providers of AIDS Care 2012-08, Vol.11 (4), p.252-259
Main Authors: Wegzyn, Colleen M, Fredrick, Linda M, Stubbs, Roxann O, Woodward, William C, Norton, Michael
Format: Article
Language:English
Subjects:
Antiretroviral drugs
Antiretroviral therapy
Antiviral drugs
Clinical trials
Diarrhea
Meta-analysis
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Summary:BackgroundAntiretroviral therapy is associated with adverse events (AEs). The most frequently reported AE associated with lopinavir/ritonavir (LPV/r) containing regimens is diarrhea. The objective of this meta-analysis is to describe the incidence, prevalence, and duration of diarrhea in individuals taking LPV/r.MethodsThis is a meta-analysis of Abbott-conducted clinical trials. Inclusion criteria included prospective randomized clinical trials with the LPV/r tablet formulation and had AE data (moderate/severe diarrhea) available through 48 weeks of treatment.ResultsThree trials (total 1469 participants) met the inclusion criteria. In all, 11.2% of participants reported moderate/severe diarrhea by week 8, with median time to resolution of 7.4 weeks. The overall 48-week incidence of moderate/severe diarrhea was 15.5%. The discontinuation rate due to moderate/severe diarrhea was 1.3%.ConclusionsModerate/severe diarrhea occurred in less than 1 in 6 participants taking LPV/r, typically started in the first 8 weeks of treatment and infrequently resulted in premature discontinuation.
ISSN:2325-9574
2325-9582
DOI:10.1177/1545109712442984