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The Hippo Pathway, YAP/TAZ, and the Plasma Membrane

The plasma membrane allows the cell to sense and adapt to changes in the extracellular environment by relaying external inputs via intracellular signaling networks. One central cellular signaling pathway is the Hippo pathway, which regulates homeostasis and plays chief roles in carcinogenesis and re...

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Bibliographic Details
Published in:Trends in cell biology 2020-01, Vol.30 (1), p.32-48
Main Authors: Rausch, Valentina, Hansen, Carsten G.
Format: Article
Language:English
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Summary:The plasma membrane allows the cell to sense and adapt to changes in the extracellular environment by relaying external inputs via intracellular signaling networks. One central cellular signaling pathway is the Hippo pathway, which regulates homeostasis and plays chief roles in carcinogenesis and regenerative processes. Recent studies have found that mechanical stimuli and diffusible chemical components can regulate the Hippo pathway primarily through receptors embedded in the plasma membrane. Morphologically defined structures within the plasma membrane, such as cellular junctions, focal adhesions, primary cilia, caveolae, clathrin-coated pits, and plaques play additional key roles. Here, we discuss recent evidence highlighting the importance of these specialized plasma membrane domains in cellular feedback via the Hippo pathway. Plasma membrane structures direct dynamic and context-specific cellular signaling via the Hippo pathway.Hippo pathway components ‘moonlight’ via interactions with plasma membrane structures.YAZ and TAZ drive expression of components involved in the generation of specialized plasma membrane domains.The Hippo pathway is integrated into multiple levels of cellular feedback.
ISSN:0962-8924
1879-3088
DOI:10.1016/j.tcb.2019.10.005