POP-Pd(ii) catalyzed easy and safe in situ carbonylation towards the synthesis of α-ketoamides from secondary cyclic amines utilizing CHCl3 as a carbon monoxide surrogate

A novel complex catalyst, POP-palladium(ii), has been synthesized. The developed catalyst has been characterized by XRD, EDX, scanning electron microscopy (FE-SEM), HR-TEM, FTIR spectroscopy, UV-vis spectroscopy, TGA and BET isotherm analysis. The reactivity of the incorporated palladium(ii) catalys...

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Bibliographic Details
Published in:New journal of chemistry 2020, Vol.44 (5), p.1979-1987
Main Authors: Islam, Sk Safikul, Riyajuddin, Sk, Rostam Ali Molla, Nasima Yasmin, Ghosh, Kaushik, Islam, Sk Manirul
Format: Article
Language:English
Subjects:
Amines
Aromatic compounds
Carbon monoxide
Carbonyls
Catalysts
Chemical synthesis
Chloroform
Iodides
Palladium
Selectivity
Spectrum analysis
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Summary:A novel complex catalyst, POP-palladium(ii), has been synthesized. The developed catalyst has been characterized by XRD, EDX, scanning electron microscopy (FE-SEM), HR-TEM, FTIR spectroscopy, UV-vis spectroscopy, TGA and BET isotherm analysis. The reactivity of the incorporated palladium(ii) catalyst was tested in the in situ carbonylation of aryl iodides and secondary cyclic amines to the respective α-ketoamides at 80 °C. A large number of aryl iodides combined with CO followed by 2° amines can generate the corresponding α-ketoamides with high selectivity. This Pd(ii) complex catalyst exhibits superb catalytic activities and can also be easily recovered after the reaction by an easy filtration method. The catalyst could be reused for up to six consecutive cycles without much loss in its activity.
ISSN:1144-0546
1369-9261
DOI:10.1039/c9nj05089b