Low molecular weight heparin aggravates infectious arthritis triggered by Staphylococcus aureus

Purpose. Staphylococcus aureus is responsible for the majority of wound infections in clean surgical procedures that involve implantation of foreign material, grafts or prosthetic devices. The aim of the study was to assess the effect of low molecular weight heparin on the development and progressio...

Full description

Saved in:
Bibliographic Details
Published in:Journal of orthopaedic research 2002-03, Vol.20 (2), p.198-203
Main Authors: Sakiniene, Egidija, Tarkowski, Andrzej
Format: Article
Language:English
Subjects:
Animals
Arthritis
Arthritis, Infectious - chemically induced
Arthritis, Infectious - microbiology
Arthritis, Infectious - pathology
Disease Models, Animal
Heparin
Heparin, Low-Molecular-Weight - adverse effects
Hypersensitivity, Delayed - drug therapy
Joints - drug effects
Joints - microbiology
Joints - pathology
Male
Mice
Mice, Inbred Strains
S. aureus
Staphylococcal Infections - pathology
Staphylococcus aureus - isolation & purification
Staphylococcus aureus - physiology
Synovitis - chemically induced
Synovitis - microbiology
Synovitis - pathology
T-Lymphocytes - drug effects
T-Lymphocytes - immunology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose. Staphylococcus aureus is responsible for the majority of wound infections in clean surgical procedures that involve implantation of foreign material, grafts or prosthetic devices. The aim of the study was to assess the effect of low molecular weight heparin on the development and progression of S. aureus arthritis. Materials and methods. The murine model of hematogenously acquired septic arthritis was used injecting intravenously toxic shock syndrome toxin-1 (TSST-1) producing S. aureus of LS-1 strain. Mice lacking prosthetic implants were treated with intraperitoneal injections of low molecular weight heparin, used routinely as anti-thrombotic prophylaxis following joint prosthetic surgery. Evaluation of arthritis was performed clinically and histopathologically. In addition, the effect of low molecular weight heparin on T cell dependent and independent inflammation was assessed. Results. Seven days after inoculation with bacteria 18 out of 19 low molecular weight heparin treated mice displayed clinical symptoms of arthritis as compared to 9 out of 23 control animals ( p
ISSN:0736-0266
1554-527X
DOI:10.1016/S0736-0266(01)00085-7