Antibody glycosylation: impact on antibody drug characteristics and quality control

Glycosylation is a common post-translational modification that occurs during the production of antibodies. Glycans attached to antibodies play an important role in the pharmacokinetics, efficacy, and safety of therapeutic antibodies. In the modern antibody industry, it is important to adjust and con...

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Bibliographic Details
Published in:Applied microbiology and biotechnology 2020-03, Vol.104 (5), p.1905-1914
Main Authors: Wang, Ziyan, Zhu, Jianwei, Lu, Huili
Format: Article
Language:English
Subjects:
Adalimumab
Antibodies
Biomedical and Life Sciences
Biopharmaceutics
Biotechnology
Glycosylation
Health aspects
Immunoglobulins
Life Sciences
Microbial Genetics and Genomics
Microbiology
Mini-Review
Pertuzumab
Pharmacokinetics
Polysaccharides
Post-translation
Quality control
Quality management
R&D
Research & development
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Summary:Glycosylation is a common post-translational modification that occurs during the production of antibodies. Glycans attached to antibodies play an important role in the pharmacokinetics, efficacy, and safety of therapeutic antibodies. In the modern antibody industry, it is important to adjust and control glycosylation modifications. The formation of specific sugar structures via glycosylation engineering is constantly evolving. This review summarizes the recent progress in glycosylation modifications, as well as the major discoveries and current understanding of the mechanisms involved, to provide new ideas for the research and development of therapeutic antibodies.
ISSN:0175-7598
1432-0614
DOI:10.1007/s00253-020-10368-7