Electrospinning of tyrosine‐based oligopeptides: Self‐assembly or forced assembly?

Short oligomeric peptides typically do not exhibit the entanglements required for the formation of nanofibers via electrospinning. In this study, the synthesis of nanofibers composed of tyrosine‐based dipeptides via electrospinning, has been demonstrated. The morphology, mechanical stiffness, biocom...

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Bibliographic Details
Published in:Journal of biomedical materials research. Part A 2020-04, Vol.108 (4), p.829-838
Main Authors: Hamedani, Yasaman, Macha, Prathyushakrishna, Evangelista, Elvira L., Sammeta, Vamshikrishna R., Chalivendra, Vijaya, Rasapalli, Sivappa, Vasudev, Milana C.
Format: Article
Language:English
Subjects:
Assembly
Biocompatibility
Biodegradability
Biodegradation
Biomaterials
Biomedical materials
Cell lines
Crosslinking
Cytotoxicity
Drug delivery
Drug delivery systems
Electrospinning
Electrostatic properties
Infrared signatures
Morphology
Nanofibers
neural cells
Oligopeptides
Peptides
Physiology
Stability
Stiffness
Surgical implants
Toxicity
Tyrosine
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Summary:Short oligomeric peptides typically do not exhibit the entanglements required for the formation of nanofibers via electrospinning. In this study, the synthesis of nanofibers composed of tyrosine‐based dipeptides via electrospinning, has been demonstrated. The morphology, mechanical stiffness, biocompatibility, and stability under physiological conditions of such biodegradable nanofibers were characterized. The electrospun peptide nanofibers have diameters less than 100 nm and high mechanical stiffness. Raman and infrared signatures of the peptide nanofibers indicate that the electrostatic forces and solvents used in the electrospinning process lead to secondary structures different from self‐assembled nanostructures composed of similar peptides. Crosslinking of the dipeptide nanofibers using 1,6‐diisohexanecyanate (HMDI) improved the physiological stability, and initial biocompatibility testing with human and rat neural cell lines indicate no cytotoxicity. Such electrospun peptides open up a realm of biomaterials design with specific biochemical compositions for potential biomedical applications such as tissue repair, drug delivery, and coatings for implants.
ISSN:1549-3296
1552-4965
DOI:10.1002/jbm.a.36861