Advances of functional nanomaterials for cancer immunotherapeutic applications

Immunotherapy has made great progress by modulating the body's own immune system to fight against cancer cells. However, the low response rates of related drugs limit the development of immunotherapy strategies. Fortunately, the advantages of nanotechnology can just make up for this shortcoming...

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Bibliographic Details
Published in:Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology 2020-03, Vol.12 (2), p.e1574-n/a
Main Authors: Hao, Yuhao, Zhou, Xingyu, Li, Rui, Song, Zechenxi, Min, Yuanzeng
Format: Article
Language:English
Subjects:
Adjuvants
Animals
Antigens
bioimaging
Biomimetics
Cancer
Cancer immunotherapy
cancer vaccine
Cancer vaccines
Chemotherapy
Drug delivery
Drug delivery systems
Drug development
Drugs
Functional materials
Humans
Immune system
Immunomodulation
immunomodulators
Immunosuppressive agents
Immunotherapy
Mice
Nanomaterials
Nanomedicine
Nanostructures
Nanotechnology
Neoplasms - therapy
Radiation therapy
Vaccines
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Summary:Immunotherapy has made great progress by modulating the body's own immune system to fight against cancer cells. However, the low response rates of related drugs limit the development of immunotherapy strategies. Fortunately, the advantages of nanotechnology can just make up for this shortcoming. Nanocarriers of diverse systems are utilized to co‐deliver antigens and adjuvants, combined with drugs for immunomodulatory, such as chemotherapy, radiotherapy, and photodynamic. Here we review recent studies on immunotherapy with biomimetic, organic, and inorganic nanomaterials. They are going to potentially overcome the drawbacks in cancer immunotherapy with delivering immunomodulatory drugs, delivering cancer vaccine, and monitoring the immune systems. This article is characterized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Schematic representation of diverse nanomaterials for immunomodulatory drugs delivery, cancer nanovaccine delivery, and monitoring the immune systems. The data for monitoring the immune systems is derived from Jeong et al. (2019). Copyright 2019, Elsevier.
ISSN:1939-5116
1939-0041
DOI:10.1002/wnan.1574