PEG-400 assisted Kröhnke synthesis of 2-(2-hydroxyphenyl)-4-arylpyridines annulated by C5-C6 cycles with substituted benzylidene group

A simple and efficient method has been developed for the synthesis 2-(2-hydroxyphenyl)-4-arylpyridines annulated by C 5 -C 6 cycles with substituted benzylidene group is achieved by multi-component Kröhnke-type reaction with moderate to good yields in PEG-400. The classical version was considered us...

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Published in:Synthetic communications 2020-03, Vol.50 (5), p.659-668
Main Authors: Batalin, Sergey, Golikova, Margarita, Khrustaleva, Alexandra, Pchelintseva, Nina
Format: Article
Language:English
Subjects:
2-(2-hydroxyphenyl)pyridines
Cross-conjugated dienones
Kröhnke reaction
PEG-400
Substitutes
Substrates
Synthesis
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container_issue 5
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container_title Synthetic communications
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creator Batalin, Sergey
Golikova, Margarita
Khrustaleva, Alexandra
Pchelintseva, Nina
description A simple and efficient method has been developed for the synthesis 2-(2-hydroxyphenyl)-4-arylpyridines annulated by C 5 -C 6 cycles with substituted benzylidene group is achieved by multi-component Kröhnke-type reaction with moderate to good yields in PEG-400. The classical version was considered using cross-conjugated dienones as substrates by counter synthesis.
doi_str_mv 10.1080/00397911.2019.1706182
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source Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Science and Technology Collection (Reading list)
subjects 2-(2-hydroxyphenyl)pyridines
Cross-conjugated dienones
Kröhnke reaction
PEG-400
Substitutes
Substrates
Synthesis
title PEG-400 assisted Kröhnke synthesis of 2-(2-hydroxyphenyl)-4-arylpyridines annulated by C5-C6 cycles with substituted benzylidene group
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