Expression of fatty-acid-binding protein 5 in intrahepatic and extrahepatic cholangiocarcinoma: the possibility of different energy metabolisms in anatomical location

• Published in: Medical molecular morphology 2020-03, Vol.53 (1), p.42-49
• Main Authors: Nakagawa, Risa, Hiep, Nguyen Canh, Ouchi, Hirofumi, Sato, Yasunori, Harada, Kenichi
• Format: Article
• Language: English
• Subjects: Adenocarcinoma - diagnosis; Adenocarcinoma - genetics; Adenocarcinoma - pathology; Adenocarcinoma - surgery; Anatomy; Bile Duct Neoplasms - diagnosis; Bile Duct Neoplasms - genetics; Bile Duct Neoplasms - pathology; Bile Duct Neoplasms - surgery; Biliary tract; Carcinogenesis; Carcinoma; Cholangiocarcinoma; Cholangiocarcinoma - diagnosis; Cholangiocarcinoma - genetics; Cholangiocarcinoma - pathology; Cholangiocarcinoma - surgery; Embryogenesis; Energy metabolism; Energy Metabolism - genetics; Epithelial cells; Epithelial Cells - metabolism; Epithelial Cells - pathology; ERRalpha Estrogen-Related Receptor; Fatty Acid-Binding Proteins - genetics; Fatty Acid-Binding Proteins - metabolism; Gallbladder cancer; Gallbladder Neoplasms - diagnosis; Gallbladder Neoplasms - genetics; Gallbladder Neoplasms - pathology; Gallbladder Neoplasms - surgery; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Medicine; Medicine & Public Health; Metabolism; Molecular Medicine; Organ Specificity; Original Paper; Pathology; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - genetics; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism; PPAR gamma - genetics; PPAR gamma - metabolism; Receptors, Estrogen - genetics; Receptors, Estrogen - metabolism
• ISSN: 1860-1480; 1860-1499
• DOI: 10.1007/s00795-019-00230-9

The biliary tract cancer (BTC) covers a range of carcinomas, including intrahepatic cholangiocarcinoma (ICC), cholangiolocellular carcinoma (CoCC), perihilar cholangiocarcinoma (perihilar CC), extrahepatic cholangiocarcinoma (ECC), and gallbladder cancer (GBC), defined according to the anatomical location. These adenocarcinomas mostly comprise biliary epithelial cell-derived malignant cells. In addition to anatomical differences, there are morphological and biological differences in BTC starting from embryonic development of the tissues extending to physiological differences. Fatty acid-binding proteins (FABPs) are closely associated with the energy metabolism. Using surgical specimens from 74 BTCs, we performed immunohistochemistry for FABP5 and its associated molecules, including peroxisome proliferator-activated receptor γ (PPARγ), PPARγ coactivator 1 (PGC-1), and estrogen-related receptor α (ERRα). We found that the expression patterns of small BTCs (ICC and CoCC) considerably differed from those of large BTCs (perihilar CC, ECC, and GBC). Expression of FABP5 and PGC-1 in large BTCs was high compared with those of small BTCs, but no difference in the expression of PPARγ and ERRα was observed. FABP5 appears to play a role in malignant progression in large BTCs. Small and large BTCs possess different energy metabolism systems owing to their different anatomical locations and course of carcinogenesis, although all BTCs originate from biliary epithelial cells.