0469 Respiratory Cycle-Related EEG Changes (RCREC) Predict All-Cause Mortality in the Sleep Heart Health Study (SHHS)

• Published in: Sleep (New York, N.Y.) N.Y.), 2019-04, Vol.42 (Supplement_1), p.A188-A189
• Main Authors: Tsimpanouli, Maria-Efstratia, Zhou, George, Dunietz, Galit L, O'Brien, Louise M, Burns, Joseph W, Chervin, Ronald D, Gliske, Stephen V
• Format: Article
• Language: English
• Subjects: Biomarkers; Electroencephalography; Health risk assessment; Mortality; Sleep
• ISSN: 0161-8105; 1550-9109
• DOI: 10.1093/sleep/zsz067.468

Introduction Sleep-disordered breathing (SDB) is among the most prevalent sleep disturbances in adults and is associated with an increased risk of death. This analysis focused on data from a large cohort of adults to assess whether an SDB biomarker based on quantitative analysis of sleep EEG, namely Respiratory Cycle-Related EEG Changes (RCREC), may in comparison to the standard apnea-hypopnea index (AHI) improve prediction of all-cause mortality. The RCREC are thought to represent breath-to-breath, inspiratory microarousals associated with increased work of breathing. Methods Data were obtained from the Sleep Heart Health Study (SHHS), a multicenter longitudinal study focused on SDB and cardiovascular health of middle-aged to older adults. The RCREC values were computed in delta (0.5-4.5 Hz), theta (4.5-8.5 Hz), alpha (8.5-12.5 Hz), sigma (12.5-15.5 Hz), beta (15.5-30.5 Hz), and gamma (30.5-49.0 Hz) frequency bands. Sequential Cox Proportional Hazard models, adjusted for body-mass index, age, race, smoking status, and sex, were used to assess association with all-cause mortality. Results Among adults with sufficient data quality (n=4427, mean age at baseline 62.8 ±10.9 (SD) years, 53% female), AHI and gamma RCREC separately showed associations with risk of mortality (adjusted OR 1.01 deaths per year per unit increase in AHI (p