4CPS-029 Preliminary results of an antimicrobial stewardship programme in an oncology department

• Published in: European journal of hospital pharmacy. Science and practice 2020-03, Vol.27 (Suppl 1), p.A60-A61
• Main Authors: Castillo-Martin, C, Martínez-Suarez, A, Retamar-Gentil, P, Sandoval-Fernandez Del Castillo, S, Murillo-Izquierdo, M
• Format: Article
• Language: English
• Subjects: Antibiotics; Antimicrobial agents; Oncology; Prescriptions
• ISSN: 2047-9956; 2047-9964
• DOI: 10.1136/ejhpharm-2020-eahpconf.130

Background and importanceMisuse of antibiotics has been related to the emergence of multidrug resistant microorganisms which are related to worse outcome in infected patients. Antimicrobial stewardship programmes (ASPs) have been shown to improve antimicrobial use.Aim and objectivesTo describe the characteristics of antimicrobial prescriptions and analyse the impact of a specific ASP implemented in an oncology department.Material and methodsA before and after ASP intervention was implemented in an oncology department in a tertiary hospital. Pre-intervention prescription characteristics were analysed through repeated point prevalence surveys in the previous year. The intervention was initiated in February 2019 based on a weekly ward round where non-tax advice was given to the oncologists about their active antibiotic prescriptions. Prescription features, rate of adherence to local guidelines and type and acceptance of the recommendations given to stop or de-escalate were recorded.ResultsA total of 62 and 73 prescriptions were included in the pre- and post-intervention periods. respectively. Table 1 describes the prescription characteristics in both periods. Adherence to local guidelines was 51% and 59% in the pre- and post-intervention periods, respectively (p=0.39).Abstract 4CPS-029 Table 1 Pre-intervention (n= 62) (n (%)) Post-intervention (n= 73) (n (%)) Men 38 (31) 44 (60) Age (years) (mean±SD) 62.18±11.5 63.78±10 Clinical syndrome Respiratory focus 15 (24) 16 (21) Urinary focus 11 (18) 5 (7) Unknown focus 10 (16) 8 (11) Intra-abdominal focus 8 (13) 8 (11) Febrile neutropenia 5 (8) 16 (22) Antimicrobials Piperacillin/tazobactam 16 (26) 22 (30) Amoxicillin/clavulanic 12 (19) 14 (19) Ceftriaxone 8 (12) 13 (18) Levofloxacin 6 (10) 4 (5) Fluconazole 5 (8) 2 (3) Adherence to guidelines 32 (51) 43 (59) In the intervention period, 26% of prescriptions were stopped and 12% de-escalated. Acceptance was 99%.Conclusion and relevanceAn ASP weekly intervention in the oncology department showed a slight increase in adherence to local antibiotic guidelines. Nevertheless, this improvement was not statistically significant due to the short follow-up period and small sample size. Further studies are required to corroborate this improvement.References and/or acknowledgementsNo conflict of interest.