Large Deformation of a DNA‐Origami Nanoarm Induced by the Cumulative Actuation of Tension‐Adjustable Modules

Making use of the programmability and structural flexibility of the DNA molecule, a DNA‐origami nanoarm capable of undergoing large deformation is constructed. This DNA‐origami nanoarm comprised serially repeated tension‐adjustable modules, the cumulative actuation of which resulted in a large defor...

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Bibliographic Details
Published in:Angewandte Chemie 2020-04, Vol.132 (15), p.6289-6293
Main Authors: Suzuki, Yuki, Kawamata, Ibuki, Mizuno, Kohei, Murata, Satoshi
Format: Article
Language:English
Subjects:
Actuation
Atomic force microscopy
Biomimetische Chemie
Chemistry
Contraction
Deformation
Deoxyribonucleic acid
DNA
DNA-Origami
External stimuli
G-Quadruplexe
Mechanische Eigenschaften
Modules
Nanotechnology devices
Selbstorganisation
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Summary:Making use of the programmability and structural flexibility of the DNA molecule, a DNA‐origami nanoarm capable of undergoing large deformation is constructed. This DNA‐origami nanoarm comprised serially repeated tension‐adjustable modules, the cumulative actuation of which resulted in a large deformation of the arm structure, which transformed from a linear shape into an arched shape. Combining atomic force microscopy and theoretical analyses based on the mechanics of materials, we demonstrate that the degree of deformation can be systematically controlled by merely replacing a set of strands that is required for the actuation of the module. Moreover, by employing a G‐quadruplex‐forming sequence for the actuation, we could achieve reversible ion‐induced contraction and relaxation of the nanoarm. The adjustability and scalability of this design could enable the production of DNA nanodevices that exhibit large deformation in response to external stimuli. Ein DNA‐Origami‐Nanoarm wurde konstruiert, der große, reversible Konformationsänderungen resultierend aus der kumulativen Wirkung serieller, zugspannungsjustierbarer Module eingehen kann. Dieser Mechanismus könnte die Produktion von DNA‐Nanofunktionseinheiten ermöglichen, die auf externe Stimuli hin ihre Form verändern.
ISSN:0044-8249
1521-3757
DOI:10.1002/ange.201916233