Manual vs automated 68Ga‐radiolabelling—A comparison of optimized processes

A critical factor for clinical practice is the production of 68Ga radiopharmaceuticals manufactured manually or through an automated procedure. 68Ga radiopharmaceuticals are often prepared manually, although this method can lead to an increased operator's radiation dose and potential variabilit...

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Bibliographic Details
Published in:Journal of labelled compounds & radiopharmaceuticals 2020-04, Vol.63 (4), p.162-173
Main Authors: Meisenheimer, Michael, Kürpig, Stefan, Essler, Markus, Eppard, Elisabeth
Format: Article
Language:English
Subjects:
Automation
cassette module
clinical routine
DOTA‐TOC
gallium‐68
PSMA‐11
Radiation dosage
Radiolabelling
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Summary:A critical factor for clinical practice is the production of 68Ga radiopharmaceuticals manufactured manually or through an automated procedure. 68Ga radiopharmaceuticals are often prepared manually, although this method can lead to an increased operator's radiation dose and potential variability within production. The present work compares 68Ga‐radiolabelling (PSMA‐11; DOTA‐TOC) utilizing a cassette module (GAIA; Elysia‐Raytest; Germany) with a manual setup for routine clinical production with regard to process reliability and reproducibility. A critical factor for clinical practice is the production of 68Ga‐radiopharmaceuticals manufactured manually or through an automated procedure. 68Ga‐radiopharmaceuticals are often prepared manually, although this method can lead to an increased operator's radiation dose and potential variability within production. The automated process is superior to manual method in all categories and presents significant improvements of 68Ga‐radiolabeling for routine clinical production in terms of reliability and reproducibility with the additional advantage of reduced operator's radiation exposure.
ISSN:0362-4803
1099-1344
DOI:10.1002/jlcr.3821